CD44: from adhesion molecules to signalling regulators
- PMID: 12511867
- DOI: 10.1038/nrm1004
CD44: from adhesion molecules to signalling regulators
Abstract
Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades. The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes--not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.
Similar articles
-
The developmental roles of the extracellular matrix: beyond structure to regulation.Cell Tissue Res. 2010 Jan;339(1):93-110. doi: 10.1007/s00441-009-0893-8. Epub 2009 Nov 3. Cell Tissue Res. 2010. PMID: 19885678 Review.
-
Adhesion proteins meet receptors: a common theme?Adv Cancer Res. 2008;101:63-92. doi: 10.1016/S0065-230X(08)00404-1. Adv Cancer Res. 2008. PMID: 19055943 Review.
-
Purified integrin adhesion complexes exhibit actin-polymerization activity.Curr Biol. 2006 Feb 7;16(3):242-51. doi: 10.1016/j.cub.2005.12.033. Curr Biol. 2006. PMID: 16461277
-
[Syndecans in cell adhesion and differentiation].Postepy Biochem. 2005;51(1):52-9. Postepy Biochem. 2005. PMID: 16209342 Review. Polish.
-
Adhesion proteins in the biology of breast cancer: contribution of CD44.Exp Mol Pathol. 1999 Jun;66(2):149-56. doi: 10.1006/exmp.1999.2251. Exp Mol Pathol. 1999. PMID: 10409443 Review.
Cited by
-
Characterization of two different alginate-based bioinks and the influence of melanoma growth within.Sci Rep. 2024 Jun 5;14(1):12945. doi: 10.1038/s41598-024-63642-3. Sci Rep. 2024. PMID: 38839791 Free PMC article.
-
Research advances in Zein-based nano-delivery systems.Front Nutr. 2024 May 9;11:1379982. doi: 10.3389/fnut.2024.1379982. eCollection 2024. Front Nutr. 2024. PMID: 38798768 Free PMC article. Review.
-
Comparative Analysis of Primary Ovarian Cancer Cells and Established Cell Lines as a New Tool for Studies on Ovarian Cancer Cell Complexity.Int J Mol Sci. 2024 May 15;25(10):5384. doi: 10.3390/ijms25105384. Int J Mol Sci. 2024. PMID: 38791431 Free PMC article.
-
Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells.Bioact Mater. 2024 May 9;38:331-345. doi: 10.1016/j.bioactmat.2024.05.011. eCollection 2024 Aug. Bioact Mater. 2024. PMID: 38764447 Free PMC article.
-
Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway.Mol Med. 2024 May 17;30(1):61. doi: 10.1186/s10020-024-00827-6. Mol Med. 2024. PMID: 38760717 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous