Mechanism and regulation of selenoprotein synthesis
- PMID: 12524431
- DOI: 10.1146/annurev.nutr.23.011702.073318
Mechanism and regulation of selenoprotein synthesis
Abstract
Selenium is an essential trace element that is incorporated into proteins as selenocysteine (Sec), the twenty-first amino acid. Sec is encoded by a UGA codon in the selenoprotein mRNA. The decoding of UGA as Sec requires the reprogramming of translation because UGA is normally read as a stop codon. The translation of selenoprotein mRNAs requires cis-acting sequences in the mRNA and novel trans-acting factors dedicated to Sec incorporation. Selenoprotein synthesis in vivo is highly selenium-dependent, and there is a hierarchy of selenoprotein expression in mammals when selenium is limiting. This review describes emerging themes from studies on the mechanism, kinetics, and efficiency of Sec insertion in prokaryotes. Recent developments that provide mechanistic insight into how the eukaryotic ribosome distinguishes between UGA/Sec and UGA/stop codons are discussed. The efficiency and regulation of mammalian selenoprotein synthesis are considered in the context of current models for Sec insertion.
Similar articles
-
The unique tRNASec and its role in selenocysteine biosynthesis.Amino Acids. 2018 Sep;50(9):1145-1167. doi: 10.1007/s00726-018-2595-6. Epub 2018 Jun 12. Amino Acids. 2018. PMID: 29948343 Review.
-
A quantitative model for the rate-limiting process of UGA alternative assignments to stop and selenocysteine codons.PLoS Comput Biol. 2017 Feb 8;13(2):e1005367. doi: 10.1371/journal.pcbi.1005367. eCollection 2017 Feb. PLoS Comput Biol. 2017. PMID: 28178267 Free PMC article.
-
Update on selenoprotein biosynthesis.Antioxid Redox Signal. 2015 Oct 1;23(10):775-94. doi: 10.1089/ars.2015.6391. Epub 2015 Aug 25. Antioxid Redox Signal. 2015. PMID: 26154496 Review.
-
Translational redefinition of UGA codons is regulated by selenium availability.J Biol Chem. 2013 Jul 5;288(27):19401-13. doi: 10.1074/jbc.M113.481051. Epub 2013 May 21. J Biol Chem. 2013. PMID: 23696641 Free PMC article.
-
Interplay between termination and translation machinery in eukaryotic selenoprotein synthesis.J Mol Biol. 2001 Jul 20;310(4):699-707. doi: 10.1006/jmbi.2001.4809. J Mol Biol. 2001. PMID: 11453681
Cited by
-
Ribosome decision graphs for the representation of eukaryotic RNA translation complexity.Genome Res. 2024 May 15;34(4):530-538. doi: 10.1101/gr.278810.123. Genome Res. 2024. PMID: 38719470 Free PMC article.
-
Selenium-More than Just a Fortuitous Sulfur Substitute in Redox Biology.Molecules. 2023 Dec 24;29(1):120. doi: 10.3390/molecules29010120. Molecules. 2023. PMID: 38202704 Free PMC article. Review.
-
Ribosome Decision Graphs for the Representation of Eukaryotic RNA Translation Complexity.bioRxiv [Preprint]. 2023 Nov 12:2023.11.10.566564. doi: 10.1101/2023.11.10.566564. bioRxiv. 2023. Update in: Genome Res. 2024 May 15;34(4):530-538. doi: 10.1101/gr.278810.123. PMID: 37986835 Free PMC article. Updated. Preprint.
-
Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study.J Transl Med. 2023 Sep 23;21(1):658. doi: 10.1186/s12967-023-04502-y. J Transl Med. 2023. PMID: 37741974 Free PMC article.
-
Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery.Nucleic Acids Res. 2023 Oct 27;51(19):10768-10781. doi: 10.1093/nar/gkad773. Nucleic Acids Res. 2023. PMID: 37739431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
