IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values
- PMID: 12738186
- DOI: 10.1016/s0278-6915(03)00021-8
IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values
Abstract
Cigarette smoke is a complex aerosol of minute liquid droplets (termed the particulate phase) suspended within a mixture of gases (CO(2), CO, NO(x), etc.) and semi-volatile compounds. The International Agency for Research on Cancer (IARC) has classified a number of the chemical constituents reported in cigarette mainstream smoke (MS) as carcinogens. Previously, we published a series of historical reviews reporting that 11 IARC Group 1 (known human), nine Group 2A (probable human) and 48 Group 2B (possible human) carcinogens have been observed in MS. Here, we expand the list of IARC classified carcinogens from 68 to 81 compounds (11 Group 1, 14 Group 2A and 56 Group 2B) reported in MS. A number of the IARC compounds reported in MS are found in the vapor phase including three Group 1, eight Group 2A and 18 Group 2B constituents. Several IARC MS compounds are found in both the vapor and particulate phases including two in Group 1, one in Group 2A and one in Group 2B. Forty-eight IARC MS carcinogens are found in the particulate phase only. Lipophilicity, as determined by the base 10 logarithm of the calculated octanol-water partition coefficient and denoted as Clog P, is reported for each of the 71 non-metallic MS IARC carcinogens. Clog P correlates with a number of biological activities including in vitro mutagenicity and carcinogenicity in rodents, and in the absence of any additional toxicological or epidemiological data, a high log P compound is more likely to be carcinogenic than a low log P compound.
Similar articles
-
Utility of the mouse dermal promotion assay in comparing the tumorigenic potential of cigarette mainstream smoke.Food Chem Toxicol. 2006 Oct;44(10):1699-706. doi: 10.1016/j.fct.2006.05.008. Epub 2006 May 26. Food Chem Toxicol. 2006. PMID: 16814916
-
"IARC Group 2B carcinogens" reported in cigarette mainstream smoke.Food Chem Toxicol. 2001 Feb;39(2):183-205. doi: 10.1016/s0278-6915(00)00164-2. Food Chem Toxicol. 2001. PMID: 11267712
-
"IARC group 2B Carcinogens" reported in cigarette mainstream smoke.Food Chem Toxicol. 2000 Sep;38(9):825-48. doi: 10.1016/s0278-6915(00)00066-1. Food Chem Toxicol. 2000. Corrected and republished in: Food Chem Toxicol. 2001 Feb;39(2):183-205. doi: 10.1016/s0278-6915(00)00164-2. PMID: 10930704 Corrected and republished. Review.
-
"IARC group 2A Carcinogens" reported in cigarette mainstream smoke.Food Chem Toxicol. 2000 Apr;38(4):371-83. doi: 10.1016/s0278-6915(99)00156-8. Food Chem Toxicol. 2000. PMID: 10722891 Review.
-
An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke.Food Chem Toxicol. 1997 Oct-Nov;35(10-11):1107-30. doi: 10.1016/s0278-6915(97)00063-x. Food Chem Toxicol. 1997. PMID: 9463546 Review.
Cited by
-
Effect of Capsule Burst in Cigarette Filters on the Compound Composition of Mainstream Cigarette Smoke.Toxics. 2023 Nov 3;11(11):901. doi: 10.3390/toxics11110901. Toxics. 2023. PMID: 37999553 Free PMC article.
-
Impact of smoking intensity and device cleaning on IQOS emissions: comparison with an array of cigarettes.Tob Control. 2024 Jun 20;33(4):449-456. doi: 10.1136/tc-2022-057802. Tob Control. 2024. PMID: 36609493 Free PMC article.
-
Genotoxicity of Marijuana in Mono-Users.Front Psychiatry. 2021 Dec 6;12:753562. doi: 10.3389/fpsyt.2021.753562. eCollection 2021. Front Psychiatry. 2021. PMID: 34938210 Free PMC article.
-
Effect of Cannabis Smoke Condensate on C. albicans Growth and Biofilm Formation.Microorganisms. 2021 Nov 13;9(11):2348. doi: 10.3390/microorganisms9112348. Microorganisms. 2021. PMID: 34835474 Free PMC article.
-
Continuous in situ portable SERS analysis of pollutants in water and air by a highly sensitive gold nanoparticle-decorated PVDF substrate.Anal Bioanal Chem. 2021 Sep;413(21):5469-5482. doi: 10.1007/s00216-021-03531-0. Epub 2021 Jul 26. Anal Bioanal Chem. 2021. PMID: 34312691
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical