Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription
- PMID: 12746498
- PMCID: PMC165814
- DOI: 10.1073/pnas.1130601100
Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription
Abstract
The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.
Figures
![Fig. 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/165814/bin/pq1130601001.gif)
![Fig. 2.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/165814/bin/pq1130601002.gif)
![Fig. 3.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/165814/bin/pq1130601003.gif)
Comment in
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RNA polymerase II at initiation.Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6893-5. doi: 10.1073/pnas.1332606100. Epub 2003 Jun 2. Proc Natl Acad Sci U S A. 2003. PMID: 12782794 Free PMC article. No abstract available.
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