Review
doi: 10.1016/s0896-6273(03)00290-3.
Synaptotagmin in Ca2+ -dependent exocytosis: dynamic action in a flash
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- PMID: 12765604
- DOI: 10.1016/s0896-6273(03)00290-3
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Review
Synaptotagmin in Ca2+ -dependent exocytosis: dynamic action in a flash
Neuron.
.
Free article
Abstract
Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as a Ca2+ trigger for synaptic vesicle exocytosis. Recent investigations have focused on structural domains of synaptotagmin that are critical for its function. Here we provide a brief overview of synaptotagmin I and discuss recent studies within the framework of neurotransmitter release mechanisms for fast synaptic transmission.
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