Role of adapters in Toll-like receptor signalling
- PMID: 12773172
- DOI: 10.1042/bst0310637
Role of adapters in Toll-like receptor signalling
Abstract
Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens within the body and the subsequent immune response. Individual TLRs recognize distinct microbial components. The TLRs are a type 1 transmembrane receptor that possess an extracellular leucine-rich repeat domain and cytoplasmic domain homologous with that of the interleukin 1 receptor (IL-1R) family. Upon stimulation, TLR recruits the IL-1R-associated kinase (IRAK) via the adapter MyD88, ultimately leading to the activation of nuclear factor-kappaB. Cytokine production in response to all TLR ligands is completely abolished in MyD88-deficient cells, indicating that MyD88 is an essential signalling molecule shared among members of the IL-1R/Toll family. However, several novel adaptor molecules have recently been identified. Evidence is now accumulating showing that differential utilization of these adaptors may activate overlapping as well as distinct signalling pathways, and ultimately give rise to distinct biological effects exerted by individual TLR family members.
Similar articles
-
Functions of toll-like receptors: lessons from KO mice.C R Biol. 2004 Jun;327(6):581-9. doi: 10.1016/j.crvi.2004.04.002. C R Biol. 2004. PMID: 15330257 Review.
-
Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling.J Infect Dis. 2003 Jun 15;187 Suppl 2:S356-63. doi: 10.1086/374749. J Infect Dis. 2003. PMID: 12792852
-
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors.J Endotoxin Res. 2003;9(1):55-9. doi: 10.1179/096805103125001351. J Endotoxin Res. 2003. PMID: 12691620 Review.
-
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.Biochim Biophys Acta. 2002 Nov 11;1592(3):265-80. doi: 10.1016/s0167-4889(02)00320-8. Biochim Biophys Acta. 2002. PMID: 12421671 Review.
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.Nature. 2001 Sep 6;413(6851):78-83. doi: 10.1038/35092578. Nature. 2001. PMID: 11544529
Cited by
-
Differential gene expression analysis using RNA-seq in the blood of goats exposed to transportation stress.Sci Rep. 2023 Feb 3;13(1):1984. doi: 10.1038/s41598-023-29224-5. Sci Rep. 2023. PMID: 36737466 Free PMC article.
-
Mycobacterium tuberculosis Rv0309 Dampens the Inflammatory Response and Enhances Mycobacterial Survival.Front Immunol. 2022 Feb 24;13:829410. doi: 10.3389/fimmu.2022.829410. eCollection 2022. Front Immunol. 2022. PMID: 35281073 Free PMC article.
-
Insights into Modern Therapeutic Approaches in Pediatric Acute Leukemias.Cells. 2022 Jan 2;11(1):139. doi: 10.3390/cells11010139. Cells. 2022. PMID: 35011701 Free PMC article. Review.
-
Interaction of preimplantation factor with the global bovine endometrial transcriptome.PLoS One. 2020 Dec 7;15(12):e0242874. doi: 10.1371/journal.pone.0242874. eCollection 2020. PLoS One. 2020. PMID: 33284816 Free PMC article.
-
IRF3 and IRF8 Regulate NF-κB Signaling by Targeting MyD88 in Teleost Fish.Front Immunol. 2020 Apr 16;11:606. doi: 10.3389/fimmu.2020.00606. eCollection 2020. Front Immunol. 2020. PMID: 32373114 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources