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. 1992 Oct 25;20(20):5465-72.
doi: 10.1093/nar/20.20.5465.

The basic RNA-binding domain of HIV-2 Tat contributes to preferential trans-activation of a TAR2-containing LTR

Y N Chang  1 , K T Jeang
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Free PMC article

The basic RNA-binding domain of HIV-2 Tat contributes to preferential trans-activation of a TAR2-containing LTR

Y N Chang et al. Nucleic Acids Res. .
Free PMC article

Abstract

Human immunodeficiency viruses HIV-1 and HIV-2 encode a Tat protein that trans-activates the respective viral genome through RNA targets (TAR1 and TAR2). Tat-1 and Tat-2 have considerable homology. However, an interesting biological observation has been that Tat-1 activates the HIV-1 and HIV-2 LTRs equally while Tat-2 activates the former, in comparison to the latter, poorly. Here, we present evidence that it is the TAR2 RNA target together with the basic RNA-binding protein domain of Tat-2 that dictate this non-reciprocity in trans-activation.

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References

    1. J Virol. 1991 Dec;65(12):6931-41 - PubMed
    1. J Virol. 1989 Dec;63(12):5501-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8510-4 - PubMed
    1. J Virol. 1990 Apr;64(4):1864-8 - PubMed
    1. Nature. 1990 Jun 14;345(6276):640-2 - PubMed

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