Insulin's expanding control of forkheads

doi:10.1073/pnas.2135308100

Comment

. 2003 Sep 30;100(20):11198-200.

doi: 10.1073/pnas.2135308100. Epub 2003 Sep 23.

Insulin's expanding control of forkheads

Michael P Czech¹

Affiliations

PMID: 14506300
PMCID: PMC208733
DOI: 10.1073/pnas.2135308100

Comment

Insulin's expanding control of forkheads

Michael P Czech. Proc Natl Acad Sci U S A. 2003.

. 2003 Sep 30;100(20):11198-200.

doi: 10.1073/pnas.2135308100. Epub 2003 Sep 23.

Author

Michael P Czech¹

Affiliation

¹ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. michael.czech@umassmed.edu

PMID: 14506300
PMCID: PMC208733
DOI: 10.1073/pnas.2135308100

No abstract available

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Figures

**Fig. 1.**
Regulation of the Foxa and Foxo transcription factors through PI3-kinase signaling. Protein kinases of the Akt/PKB and SGK families (for review, see ref. 35) downstream of 3′ polyphosphoinositides generated by PI3-kinase mediate phosphorylation and cytoplasmic localization of Foxa2 and three Foxo isoforms. Thus, insulin, IGF-1, and other regulators of PI3-kinase attenuate transcriptional activity of these proteins. Foxa2 regulates gene expression in the context of Foxa1 and Foxa3 actions, which are not regulated by PI3-kinase. Overlapping but distinct specificities of the Foxa and Foxo proteins for promoter sequences provide a complex network of transcriptional signals that can finely modulate sets of genes (A, B, C, and D) in a metabolic or developmental pathway.

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Comment on

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
Wolfrum C, Besser D, Luca E, Stoffel M. Wolfrum C, et al. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11624-9. doi: 10.1073/pnas.1931483100. Epub 2003 Sep 19. Proc Natl Acad Sci U S A. 2003. PMID: 14500912 Free PMC article.

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References

1. Carlsson, P. & Mahlapuu, M. (2002) Dev. Biol. 250, 1–23. - PubMed
1. Kaestner, K. H., Knochel, W. & Martinez, D. E. (2000) Genes Dev. 14, 142–146. - PubMed
1. Altomonte, J., Richter, A., Harbaran, S., Suriawinata, J., Nakae, J., Thung, S. N., Meseck, M., Accili, D. & Dong, H. (2003) Am. J. Physiol., in press. - PubMed
1. Kaestner, K. H. (2000) Trends Endocrinol. Metab. 11, 281–285. - PubMed
1. Wolfrum, C., Besser, D., Luca, E. & Stoffel, M. (2003) Proc. Natl. Acad. Sci. USA 100, 11624–11629. - PMC - PubMed

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[1] Carlsson, P. & Mahlapuu, M. (2002) Dev. Biol. 250, 1–23. - PubMed

[2] Carlsson, P. & Mahlapuu, M. (2002) Dev. Biol. 250, 1–23. - PubMed

[3] Kaestner, K. H., Knochel, W. & Martinez, D. E. (2000) Genes Dev. 14, 142–146. - PubMed

[4] Kaestner, K. H., Knochel, W. & Martinez, D. E. (2000) Genes Dev. 14, 142–146. - PubMed

[5] Altomonte, J., Richter, A., Harbaran, S., Suriawinata, J., Nakae, J., Thung, S. N., Meseck, M., Accili, D. & Dong, H. (2003) Am. J. Physiol., in press. - PubMed

[6] Altomonte, J., Richter, A., Harbaran, S., Suriawinata, J., Nakae, J., Thung, S. N., Meseck, M., Accili, D. & Dong, H. (2003) Am. J. Physiol., in press. - PubMed

[7] Kaestner, K. H. (2000) Trends Endocrinol. Metab. 11, 281–285. - PubMed

[8] Kaestner, K. H. (2000) Trends Endocrinol. Metab. 11, 281–285. - PubMed

[9] Wolfrum, C., Besser, D., Luca, E. & Stoffel, M. (2003) Proc. Natl. Acad. Sci. USA 100, 11624–11629. - PMC - PubMed

[10] Wolfrum, C., Besser, D., Luca, E. & Stoffel, M. (2003) Proc. Natl. Acad. Sci. USA 100, 11624–11629. - PMC - PubMed

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Insulin's expanding control of forkheads

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