Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling
- PMID: 14511481
- PMCID: PMC1693235
- DOI: 10.1098/rstb.2003.1332
Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling
Abstract
Prior to gastrulation the mouse embryo exists as a symmetrical cylinder consisting of three tissue layers. Positioning of the future anterior-posterior axis of the embryo occurs through coordinated cell movements that rotate a pre-existing proximal-distal (P-D) axis. Overt axis formation becomes evident when a discrete population of proximal epiblast cells become induced to form mesoderm, initiating primitive streak formation and marking the posterior side of the embryo. Over the next 12-24 h the primitive streak gradually elongates along the posterior side of the epiblast to reach the distal tip. The most anterior streak cells comprise the 'organizer' region and include the precursors of the so-called 'axial mesendoderm', namely the anterior definitive endoderm and prechordal plate mesoderm, as well as those cells that give rise to the morphologically patent node. Signalling pathways controlled by the transforming growth factor-beta ligand nodal are involved in orchestrating the process of axis formation. Embryos lacking nodal activity arrest development before gastrulation, reflecting an essential role for nodal in establishing P-D polarity by generating and maintaining the molecular pattern within the epiblast, extraembryonic ectoderm and the visceral endoderm. Using a genetic strategy to manipulate temporal and spatial domains of nodal expression reveals that the nodal pathway is also instrumental in controlling both the morphogenetic movements required for orientation of the final axis and for specification of the axial mesendoderm progenitors.
Similar articles
-
Cell fate decisions within the mouse organizer are governed by graded Nodal signals.Genes Dev. 2003 Jul 1;17(13):1646-62. doi: 10.1101/gad.1100503. Genes Dev. 2003. PMID: 12842913 Free PMC article.
-
Building the mouse gastrula: signals, asymmetry and lineages.Curr Opin Genet Dev. 2006 Aug;16(4):419-25. doi: 10.1016/j.gde.2006.06.008. Epub 2006 Jun 21. Curr Opin Genet Dev. 2006. PMID: 16793258 Review.
-
Nodal signalling in the epiblast patterns the early mouse embryo.Nature. 2001 Jun 21;411(6840):965-9. doi: 10.1038/35082103. Nature. 2001. PMID: 11418863
-
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.Nature. 1998 Oct 15;395(6703):702-7. doi: 10.1038/27215. Nature. 1998. PMID: 9790191
-
Nodal signalling in vertebrate development.Nature. 2000 Jan 27;403(6768):385-9. doi: 10.1038/35000126. Nature. 2000. PMID: 10667782 Review.
Cited by
-
A chemically defined system supports two distinct types of stem cell from a single blastocyst and their self-assembly to generate blastoid.Cell Prolif. 2023 Jun;56(6):e13396. doi: 10.1111/cpr.13396. Epub 2023 Jan 2. Cell Prolif. 2023. PMID: 36593753 Free PMC article.
-
Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning.Sci Adv. 2021 Mar 10;7(11):eabe1640. doi: 10.1126/sciadv.abe1640. Print 2021 Mar. Sci Adv. 2021. PMID: 33692105 Free PMC article.
-
Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.Dev Biol. 2020 Aug 15;464(2):161-175. doi: 10.1016/j.ydbio.2020.05.010. Epub 2020 Jun 21. Dev Biol. 2020. PMID: 32579954 Free PMC article.
-
TGFβ Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells' Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer.Cells. 2019 Nov 23;8(12):1500. doi: 10.3390/cells8121500. Cells. 2019. PMID: 31771212 Free PMC article. Review.
-
Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells.Nat Commun. 2019 Jan 30;10(1):496. doi: 10.1038/s41467-019-08378-9. Nat Commun. 2019. PMID: 30700702 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases