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Review
. 2003 Oct;4(10):763-73.
doi: 10.1038/nrg1178.

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family

Kristin A Waite  1 , Charis Eng
Affiliations
Review

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family

Kristin A Waite et al. Nat Rev Genet. 2003 Oct.

Abstract

Transforming growth factor-beta (TGF-beta) regulates many cellular processes through complex signal-transduction pathways that have crucial roles in normal development. Disruption of these pathways can lead to a range of diseases, including cancer. Mutations in the genes that encode members of the TGF-beta pathway are involved in vascular diseases as well as gastrointestinal neoplasia. More recently, they have been implicated in Cowden syndrome, which is normally associated with mutations in the phosphatase and tensin homologue gene PTEN. Molecular studies of TGF-beta signalling are now showing why mutations in genes that encode components of this pathway result in inherited cancer and developmental diseases.

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