Antigenic characterization of the live attenuated Japanese encephalitis vaccine virus SA14-14-2: a comparison with isolates of the virus covering a wide geographic area
- PMID: 1455912
- DOI: 10.1016/0264-410x(92)90051-k
Antigenic characterization of the live attenuated Japanese encephalitis vaccine virus SA14-14-2: a comparison with isolates of the virus covering a wide geographic area
Abstract
In China, a live attenuated Japanese encephalitis (JE) vaccine, based on strain SA14-14-2, has been derived from the wild-type strain SA14 as an alternative to the current inactivated vaccines such as Nakayama-NIH and P-3. SA14-14-2 has been characterized using monoclonal antibodies derived in mice, using HAI and neutralization tests, and compared with other Chinese live vaccine clones and 14 wild-type strains of JE virus. Wild-type strain SA14 was found to be a poor immunogen and antigenically distant from all other viruses examined. The vaccine derivatives SA14-5-3 was more immunogenic than its wild-type parent, while SA14-14-2 (derived from SA14-5-3) was more immunogenic than SA14-5-3 and elicited a cross neutralizing antibody response. Our studies indicated that JE virus strain Nakayama elicited as good a neutralizing antibody response in hyperimmunized mice as the SA14-14-2 vaccine clones grown in either primary hamster kidney (PHK) or primary dog kidney (PDK) cells. A single dose of live SA14-14-2 (PHK) also elicited a good antibody response. Antigenic variation between wild-type and vaccine clones of JE virus were detected but were not considered significant in terms of controlling JE virus infections by vaccination.
Similar articles
-
Phenotypic and genotypic characteristics of Japanese encephalitis attenuated live vaccine virus SA14-14-2 and their stabilities.Vaccine. 2010 May 7;28(21):3635-41. doi: 10.1016/j.vaccine.2010.02.105. Epub 2010 Mar 11. Vaccine. 2010. PMID: 20226891 Review.
-
Japanese encephalitis vaccines: current vaccines and future prospects.Curr Top Microbiol Immunol. 2002;267:105-38. doi: 10.1007/978-3-642-59403-8_6. Curr Top Microbiol Immunol. 2002. PMID: 12082985 Review.
-
Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates.Vaccine. 1999 Apr 9;17(15-16):1869-82. doi: 10.1016/s0264-410x(98)00487-3. Vaccine. 1999. PMID: 10217584
-
Immunogenicity of wild-type and vaccine strains of Japanese encephalitis virus and the effect of haplotype restriction on murine immune responses.Vaccine. 1993;11(7):761-6. doi: 10.1016/0264-410x(93)90262-v. Vaccine. 1993. PMID: 8342323
-
Immunogenicity of experimental live attenuated Japanese encephalitis vaccine viruses and comparison with wild-type strains using monoclonal and polyclonal antibodies.Vaccine. 1992;10(5):329-33. doi: 10.1016/0264-410x(92)90372-q. Vaccine. 1992. PMID: 1315470
Cited by
-
Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity.NPJ Vaccines. 2021 Sep 2;6(1):112. doi: 10.1038/s41541-021-00371-y. NPJ Vaccines. 2021. PMID: 34475404 Free PMC article.
-
Full-Length Genome Sequence of Japanese Encephalitis Virus Strain FC792, Isolated from Guangxi, China.Genome Announc. 2017 Nov 30;5(48):e01054-17. doi: 10.1128/genomeA.01054-17. Genome Announc. 2017. PMID: 29192069 Free PMC article.
-
Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 Strain.Viruses. 2017 Jan 21;9(1):20. doi: 10.3390/v9010020. Viruses. 2017. PMID: 28117725 Free PMC article.
-
Persistence of Wild-Type Japanese Encephalitis Virus Strains Cross-Neutralization 5 Years After JE-CV Immunization.J Infect Dis. 2017 Jan 15;215(2):221-227. doi: 10.1093/infdis/jiw533. J Infect Dis. 2017. PMID: 27815383 Free PMC article. Clinical Trial.
-
Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.J Neurovirol. 2014 Dec;20(6):539-60. doi: 10.1007/s13365-014-0285-z. Epub 2014 Oct 7. J Neurovirol. 2014. PMID: 25287260 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
