Increased expression of Bcl-xL and c-Myc is associated with transformation by Abelson murine leukemia virus
- PMID: 14559912
- DOI: 10.1074/jbc.M306629200
Increased expression of Bcl-xL and c-Myc is associated with transformation by Abelson murine leukemia virus
Abstract
Transformation mediated by the v-Abl oncoprotein, a tyrosine kinase encoded by the Abelson murine leukemia virus, is a multi-step process requiring genetic alterations in addition to expression of v-Abl. Loss of p53 or p19ARF was previously shown to be required for Abelson murine leukemia virus transformation of primary mouse embryonic fibroblasts (MEFs). By comparing gene expression patterns in primary p53-/- MEFs acutely infected with the v-Abl retrovirus, v-Abl-transformed MEF clones, and v-Abl-transformed MEF clones treated with Abl kinase inhibitor STI 571, we have identified additional genetic alterations associated with v-Abl transformation. Bcl-xL mRNA was elevated in three of five v-Abl-transformed MEF clones. In addition, elevated expression of c-Myc mRNA, caused either by c-myc gene amplification or by enhanced signaling via STAT3, was observed in five v-Abl-transformed MEF clones. The data suggest that increases in cell survival associated with Bcl-xL and increases in cell growth associated with c-Myc facilitate the transformation process dependent on constitutive mitogenic signaling by v-Abl.
Similar articles
-
IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.J Immunol. 1998 Nov 1;161(9):4611-7. J Immunol. 1998. PMID: 9794389
-
Inhibition of v-Abl transformation by p53 and p19ARF.Oncogene. 1999 Dec 16;18(54):7731-9. doi: 10.1038/sj.onc.1203290. Oncogene. 1999. PMID: 10618713
-
Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain.J Virol. 2001 Feb;75(4):1816-23. doi: 10.1128/JVI.75.4.1816-1823.2001. J Virol. 2001. PMID: 11160680 Free PMC article.
-
[Mechanism underlying tumorigenesis induced by Bcr-Abl oncogene and A-MuLV virus].Sheng Wu Gong Cheng Xue Bao. 2018 Dec 25;34(12):1943-1952. doi: 10.13345/j.cjb.180183. Sheng Wu Gong Cheng Xue Bao. 2018. PMID: 30584705 Review. Chinese.
-
Inhibition of Abelson oncogene function by erbstatin analogues.Drugs Exp Clin Res. 1993;19(6):235-41. Drugs Exp Clin Res. 1993. PMID: 8013266 Review.
Cited by
-
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia.Blood. 2020 Sep 24;136(13):1520-1534. doi: 10.1182/blood.2019002655. Blood. 2020. PMID: 32396934 Free PMC article.
-
Induction of Constitutive High-Level Expression of c-Myc in 32D Cells by Mycoplasmas is Associated with their Ability to Prevent Apoptosis and Induce Malignant Transformation.Int J Biomed Sci. 2006 Dec;2(4):324-32. Int J Biomed Sci. 2006. PMID: 23675000 Free PMC article.
-
Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.J Virol. 2008 Sep;82(17):8383-91. doi: 10.1128/JVI.00348-08. Epub 2008 Jun 25. J Virol. 2008. PMID: 18579612 Free PMC article.
-
E2A promotes the survival of precursor and mature B lymphocytes.J Immunol. 2006 Aug 15;177(4):2495-504. doi: 10.4049/jimmunol.177.4.2495. J Immunol. 2006. PMID: 16888011 Free PMC article.
-
Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice.J Clin Invest. 2004 Jun;113(12):1763-73. doi: 10.1172/JCI20369. J Clin Invest. 2004. PMID: 15199411 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
