Histone sumoylation is associated with transcriptional repression
- PMID: 14578449
- PMCID: PMC263760
- DOI: 10.1073/pnas.1735528100
Histone sumoylation is associated with transcriptional repression
Abstract
Histone proteins are subject to modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of which are known to play important roles in the regulation of chromatin structure and function. Here we report that histone H4 is modified by small ubiquitin-related modifier (SUMO) family proteins both in vivo and in vitro. H4 binds to the SUMO-conjugating enzyme (E2), UBC9, and can be sumoylated in an E1 (SUMO-activating enzyme)- and E2-dependent manner. We present evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1.
Figures
![Fig. 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/263760/bin/pq2135528001.gif)
![Fig. 2.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/263760/bin/pq2135528002.gif)
![Fig. 3.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/263760/bin/pq2135528003.gif)
![Fig. 4.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/263760/bin/pq2135528004.gif)
![Fig. 5.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/263760/bin/pq2135528005.gif)
Comment in
-
Histone modifications: Now summoning sumoylation.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20. doi: 10.1073/pnas.2436173100. Epub 2003 Nov 3. Proc Natl Acad Sci U S A. 2003. PMID: 14597707 Free PMC article. No abstract available.
Similar articles
-
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.Mol Cell Biol. 2005 Oct;25(19):8456-64. doi: 10.1128/MCB.25.19.8456-8464.2005. Mol Cell Biol. 2005. PMID: 16166628 Free PMC article.
-
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.Nucleic Acids Res. 2004 Jan 29;32(2):598-610. doi: 10.1093/nar/gkh195. Print 2004. Nucleic Acids Res. 2004. PMID: 14752048 Free PMC article.
-
Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.Mol Cell Biol. 2005 Oct;25(19):8415-29. doi: 10.1128/MCB.25.19.8415-8429.2005. Mol Cell Biol. 2005. PMID: 16166625 Free PMC article.
-
SUMO association with repressor complexes, emerging routes for transcriptional control.Biochim Biophys Acta. 2009 Jun-Aug;1789(6-8):451-9. doi: 10.1016/j.bbagrm.2009.07.001. Epub 2009 Jul 17. Biochim Biophys Acta. 2009. PMID: 19616654 Review.
-
Transcriptional regulation by C-terminal binding proteins.Int J Biochem Cell Biol. 2007;39(9):1593-607. doi: 10.1016/j.biocel.2007.01.025. Epub 2007 Feb 4. Int J Biochem Cell Biol. 2007. PMID: 17336131 Review.
Cited by
-
An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions.Int J Mol Sci. 2024 Mar 30;25(7):3881. doi: 10.3390/ijms25073881. Int J Mol Sci. 2024. PMID: 38612690 Free PMC article. Review.
-
Epigenetic Regulation of Autophagy in Bone Metabolism.Function (Oxf). 2024 Jan 27;5(2):zqae004. doi: 10.1093/function/zqae004. eCollection 2024. Function (Oxf). 2024. PMID: 38486976 Free PMC article. Review.
-
Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants.Proteomes. 2023 Nov 22;11(4):38. doi: 10.3390/proteomes11040038. Proteomes. 2023. PMID: 38133152 Free PMC article. Review.
-
SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes.Elife. 2023 Nov 24;12:RP89493. doi: 10.7554/eLife.89493. Elife. 2023. PMID: 37999956 Free PMC article.
-
Updates in pathobiological aspects of anaplastic large cell lymphoma.Front Oncol. 2023 Sep 22;13:1241532. doi: 10.3389/fonc.2023.1241532. eCollection 2023. Front Oncol. 2023. PMID: 37810974 Free PMC article. Review.
References
-
- Strahl, B. D. & Allis, C. D. (2000) Nature 403, 41-45. - PubMed
-
- Berger, S. L. (2001) Oncogene 20, 3007-3013. - PubMed
-
- Kuo, M. H. & Allis, C. D. (1998) BioEssays 20, 615-626. - PubMed
-
- Melchior, F. (2000) Annu. Rev. Cell Dev. Biol. 16, 591-626. - PubMed
-
- Hay, R. T. (2001) Trends Biochem. Sci. 26, 332-333. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous