Analysis of aristolochic acid in nine sources of Xixin, a traditional Chinese medicine, by liquid chromatography/atmospheric pressure chemical ionization/tandem mass spectrometry
- PMID: 14623612
- DOI: 10.1016/s0731-7085(03)00310-8
Analysis of aristolochic acid in nine sources of Xixin, a traditional Chinese medicine, by liquid chromatography/atmospheric pressure chemical ionization/tandem mass spectrometry
Abstract
Aristolochic acid I (AA-I), which is a known nephrotoxin, is found in a commonly used Chinese medicine, Xixin, that originates from nine Asarum species (Aristolochiaceae) found in China. A method has been developed using reversed-phase liquid chromatography coupled with atmospheric pressure chemical ionization (APCI) tandem mass spectrometry under the positive ion detection mode [LC/(+)APCI/MS/MS] to determine the amount of AA-I in Xixin. The limit of detection of AA-I, estimated by monitoring with LC/MS/MS, was at the low microg/l level. By applying this method to methanol extracts of nine Asarum species, the concentrations of AA-I were found to range from 3.3 ng/mg (Asarum sieboldii) to 3376.9 ng/mg (Asarum crispulatum).
Similar articles
-
Rapid determination of aristolochic acids I and II in herbal products and biological samples by ultra-high-pressure liquid chromatography-tandem mass spectrometry.Talanta. 2010 Mar 15;80(5):1672-80. doi: 10.1016/j.talanta.2009.10.003. Epub 2009 Oct 12. Talanta. 2010. PMID: 20152395
-
[Determination of aristolochic acids A and B in Chinese herbals and traditional Chinese patent medicines using ultra high performance liquid chromatography-triple quadrupole mass spectrometry].Se Pu. 2011 Nov;29(11):1076-81. Se Pu. 2011. PMID: 22393694 Chinese.
-
Rapid simultaneous determination of thirteen aristolochic acids analogs in Aristolochiaceae plants by Ultra-High-Performance liquid Chromatography- tandem mass spectrometry in dynamic multiple reaction monitoring mode.J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jun 1;1225:123753. doi: 10.1016/j.jchromb.2023.123753. Epub 2023 May 15. J Chromatogr B Analyt Technol Biomed Life Sci. 2023. PMID: 37216764
-
Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry.J Chromatogr A. 2009 Mar 13;1216(11):2045-62. doi: 10.1016/j.chroma.2008.08.097. Epub 2008 Sep 3. J Chromatogr A. 2009. PMID: 18804769 Review.
-
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine.Mass Spectrom Rev. 2024 Sep-Oct;43(5):1150-1171. doi: 10.1002/mas.21866. Epub 2023 Aug 20. Mass Spectrom Rev. 2024. PMID: 37598314 Review.
Cited by
-
Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review.Molecules. 2023 Dec 22;29(1):81. doi: 10.3390/molecules29010081. Molecules. 2023. PMID: 38202664 Free PMC article. Review.
-
Latency period of aristolochic acid-induced upper urinary tract urothelial carcinoma.Front Public Health. 2023 Mar 9;11:1072864. doi: 10.3389/fpubh.2023.1072864. eCollection 2023. Front Public Health. 2023. PMID: 36969664 Free PMC article.
-
Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review.World J Urol. 2023 Apr;41(4):899-907. doi: 10.1007/s00345-022-04100-5. Epub 2022 Jul 22. World J Urol. 2023. PMID: 35867141
-
Chromosome-level genome assembly of Aristolochia contorta provides insights into the biosynthesis of benzylisoquinoline alkaloids and aristolochic acids.Hortic Res. 2022 Feb 11;9:uhac005. doi: 10.1093/hr/uhac005. Online ahead of print. Hortic Res. 2022. PMID: 35147168 Free PMC article.
-
Quantitative Determination and Toxicity Evaluation of Aristolochic Acid Analogues in Asarum heterotropoides F. Schmidt (Xixin) and Traditional Chinese Patent Medicines.Front Pharmacol. 2021 Nov 26;12:761593. doi: 10.3389/fphar.2021.761593. eCollection 2021. Front Pharmacol. 2021. PMID: 34899315 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources