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. 2003 Dec;130(25):6283-94.
doi: 10.1242/dev.00859.

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Markus Morkel  1 , Joerg Huelsken, Maki Wakamiya, Jixiang Ding, Marc van de Wetering, Hans Clevers, Makoto M Taketo, Richard R Behringer, Michael M Shen, Walter Birchmeier
Affiliations

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Markus Morkel et al. Development. 2003 Dec.

Abstract

Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.

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