NF-kappaB in mammary gland development and breast cancer
- PMID: 14635796
- DOI: 10.1023/a:1025905008934
NF-kappaB in mammary gland development and breast cancer
Abstract
Nuclear factor of kappaB (NF-kappaB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-kappaB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-kappaB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-kappaB may play an important role in the etiology of breast cancer. Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.
Similar articles
-
RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland.Mol Cell Biol. 2005 Nov;25(22):10136-47. doi: 10.1128/MCB.25.22.10136-10147.2005. Mol Cell Biol. 2005. PMID: 16260626 Free PMC article.
-
p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.J Biol Chem. 2004 Jan 9;279(2):1422-8. doi: 10.1074/jbc.M309937200. Epub 2003 Oct 6. J Biol Chem. 2004. PMID: 14530270
-
Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression.FASEB J. 2000 Jun;14(9):1159-70. doi: 10.1096/fasebj.14.9.1159. FASEB J. 2000. PMID: 10834938
-
Progesterone receptors in mammary gland development and tumorigenesis.J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):205-14. doi: 10.1023/a:1025952924864. J Mammary Gland Biol Neoplasia. 2003. PMID: 14635795 Review.
-
Ectodysplasin/NF-κB signaling in embryonic mammary gland development.J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):165-9. doi: 10.1007/s10911-013-9277-5. Epub 2013 Apr 17. J Mammary Gland Biol Neoplasia. 2013. PMID: 23591968 Review.
Cited by
-
Establishment of canine mammary gland tumor cell lines harboring PI3K/Akt activation as a therapeutic target.BMC Vet Res. 2024 May 29;20(1):233. doi: 10.1186/s12917-024-04085-w. BMC Vet Res. 2024. PMID: 38807154 Free PMC article.
-
Noscapine and Apoptosis in Breast and Other Cancers.Int J Mol Sci. 2024 Mar 21;25(6):3536. doi: 10.3390/ijms25063536. Int J Mol Sci. 2024. PMID: 38542508 Free PMC article. Review.
-
Rel-A/PACER/miR 7 Axis May Play a Role in Radiotherapy Treatment in Breast Cancer Patients.Iran Biomed J. 2023 Jul 1;27(4):173-82. doi: 10.61186/ibj.3901. Iran Biomed J. 2023. PMID: 37507347 Free PMC article.
-
Cell type and stage specific transcriptional, chromatin and cell-cell communication landscapes in the mammary gland.Heliyon. 2023 Jun 30;9(7):e17842. doi: 10.1016/j.heliyon.2023.e17842. eCollection 2023 Jul. Heliyon. 2023. PMID: 37456014 Free PMC article.
-
Sodium salicylate reduced mRNA abundance of hypoxia-associated genes in MAC-T cells.JDS Commun. 2021 Mar 26;2(3):159-164. doi: 10.3168/jdsc.2020-0037. eCollection 2021 May. JDS Commun. 2021. PMID: 36339495 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous