Immunity regulatory DNAs share common organizational features in Drosophila
- PMID: 14731391
- DOI: 10.1016/s1097-2765(03)00500-8
Immunity regulatory DNAs share common organizational features in Drosophila
Abstract
Infection results in the rapid activation of immunity genes in the Drosophila fat body. Two classes of transcription factors have been implicated in this process: the REL-containing proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent. Here we present evidence that REL-GATA synergy plays a pervasive role in the immune response. SELEX assays identified consensus binding sites that permitted the characterization of several immunity regulatory DNAs. The distribution of REL and GATA sites within these DNAs suggests that most or all fat-specific immunity genes contain a common organization of regulatory elements: closely linked REL and GATA binding sites positioned in the same orientation and located near the transcription start site. Aspects of this "regulatory code" are essential for the immune response. These results suggest that immunity regulatory DNAs contain constrained organizational features, which may be a general property of eukaryotic enhancers.
Comment in
-
Learning the codes of fly immunity.Mol Cell. 2004 Jan 16;13(1):1-2. doi: 10.1016/s1097-2765(03)00525-2. Mol Cell. 2004. PMID: 14731387
Similar articles
-
Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif.EMBO J. 1999 Jul 15;18(14):4013-22. doi: 10.1093/emboj/18.14.4013. EMBO J. 1999. PMID: 10406806 Free PMC article.
-
Learning the codes of fly immunity.Mol Cell. 2004 Jan 16;13(1):1-2. doi: 10.1016/s1097-2765(03)00525-2. Mol Cell. 2004. PMID: 14731387
-
DEAF-1 regulates immunity gene expression in Drosophila.Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8351-6. doi: 10.1073/pnas.0802921105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550807 Free PMC article.
-
Molecular genetics of Drosophila immunity.Curr Opin Genet Dev. 1994 Oct;4(5):672-7. doi: 10.1016/0959-437x(94)90133-n. Curr Opin Genet Dev. 1994. PMID: 7849506 Review.
-
One thousand and one ways of making functionally similar transcriptional enhancers.Bioessays. 2008 Nov;30(11-12):1052-7. doi: 10.1002/bies.20849. Bioessays. 2008. PMID: 18937349 Review.
Cited by
-
The genome of the ant Tetramorium bicarinatum reveals a tandem organization of venom peptides genes allowing the prediction of their regulatory and evolutionary profiles.BMC Genomics. 2024 Jan 20;25(1):84. doi: 10.1186/s12864-024-10012-y. BMC Genomics. 2024. PMID: 38245722 Free PMC article.
-
The role of micro RNAs (miRNAs) in the regulation of Drosophila melanogaster's innate immunity.Fly (Austin). 2022 Dec;16(1):382-396. doi: 10.1080/19336934.2022.2149204. Fly (Austin). 2022. PMID: 36412256 Free PMC article. Review.
-
Trans-regulatory changes underpin the evolution of the Drosophila immune response.PLoS Genet. 2022 Nov 7;18(11):e1010453. doi: 10.1371/journal.pgen.1010453. eCollection 2022 Nov. PLoS Genet. 2022. PMID: 36342922 Free PMC article.
-
Meta-Analysis of Immune Induced Gene Expression Changes in Diverse Drosophila melanogaster Innate Immune Responses.Insects. 2022 May 23;13(5):490. doi: 10.3390/insects13050490. Insects. 2022. PMID: 35621824 Free PMC article.
-
SUMOylation of Dorsal attenuates Toll/NF-κB signaling.Genetics. 2022 Jul 4;221(3):iyac081. doi: 10.1093/genetics/iyac081. Genetics. 2022. PMID: 35567478 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
