Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004:10 Suppl 1:82-90.
doi: 10.1080/753312757.

Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis

Adeline Nukuna  1 , Howard E Gendelman, Jenae Limoges, Jennifer Rasmussen, Larisa Poluektova, Anuja Ghorpade, Yuri Persidsky
Affiliations

Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis

Adeline Nukuna et al. J Neurovirol. 2004.

Abstract

The presence of specific neuroinvasive strains and necessity for brain viral replication for disease progression remain controversial issues in neuro-AIDS research. To investigate these questions, the authors injected human monocyte-derived macrophages (MDMs) infected with diverse viral strains were injected into the caudate and putamen of severe combined immunodeficient (SCID) mice. Independent of viral strain, infected MDMs became immunologically activated and elicited profound inflammatory reactions in brain areas most affected in humans. The intensity of neuropathologic changes, including microglial reactions, paralleled levels of viral infection and numbers of infected MDMs. The data suggest that HIV-1-associated neurological disease is related to the level of productive viral infection in activated macrophages. Virus infection, per se, may affect the ability of macrophages to respond to immune stimuli by overproduction of proinflammatory factors and neurotoxins, leading to neuronal dysfunction.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Science. 1986 Jul 11;233(4760):215-9 - PubMed
    1. J Acquir Immune Defic Syndr. 2002 Oct 1;31(2):171-7 - PubMed
    1. Am J Pathol. 1996 Sep;149(3):1027-53 - PubMed
    1. Semin Immunol. 1998 Jun;10(3):203-13 - PubMed
    1. Science. 1988 Feb 5;239(4840):586-92 - PubMed

Publication types

LinkOut - more resources

-