Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study
- PMID: 15126436
- DOI: 10.1001/jama.291.17.2086
Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study
Abstract
Context: The duration of protection from tuberculosis of BCG vaccines is not known.
Objective: To determine the long-term duration of protection of a BCG vaccine that was previously found to be efficacious.
Design: Retrospective record review using Indian Health Service records, tuberculosis registries, death certificates, and supplemental interviews with trial participants.
Setting and participants: Follow-up for the period 1948-1998 among American Indians and Alaska Natives who participated in a placebo-controlled BCG vaccine trial during 1935-1938 and who were still at risk of developing tuberculosis. Data from 1483 participants in the BCG vaccine group and 1309 in the placebo group were analyzed.
Main outcome measures: Efficacy of BCG vaccine, calculated for each 10-year interval using a Cox regression model with time-dependent variables based on tuberculosis events occurring after December 31, 1947 (end of prospective case finding).
Results: The overall incidence of tuberculosis was 66 and 138 cases per 100 000 person-years in the BCG vaccine and placebo groups, respectively, for an estimate of vaccine efficacy of 52% (95% confidence interval, 27%-69%). Adjustments for age at vaccination, tribe, subsequent BCG vaccination, chronic medical illness, isoniazid use, and bacille Calmette-Guérin strain did not substantially affect vaccine efficacy. There was slight but not statistically significant waning of the efficacy of BCG vaccination over time, greater among men than women.
Conclusion: In this trial, BCG vaccine efficacy persisted for 50 to 60 years, suggesting that a single dose of an effective BCG vaccine can have a long duration of protection.
Comment in
-
A booster for tuberculosis vaccines.JAMA. 2004 May 5;291(17):2127-8. doi: 10.1001/jama.291.17.2127. JAMA. 2004. PMID: 15126443 No abstract available.
Similar articles
-
Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses: A 60-Year Follow-up of a Clinical Trial.JAMA Netw Open. 2019 Sep 4;2(9):e1912014. doi: 10.1001/jamanetworkopen.2019.12014. JAMA Netw Open. 2019. PMID: 31553471 Free PMC article.
-
BCG vaccination among Canadian Indians and Inuit: the epidemiological bases for policy decision.Can J Public Health. 1985 Mar-Apr;76(2):124-9. Can J Public Health. 1985. PMID: 4005772
-
Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis.Health Technol Assess. 2013 Sep;17(37):1-372, v-vi. doi: 10.3310/hta17370. Health Technol Assess. 2013. PMID: 24021245 Free PMC article. Review.
-
The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature.Pediatrics. 1995 Jul;96(1 Pt 1):29-35. Pediatrics. 1995. PMID: 7596718
-
Recent developments in tuberculosis vaccines.Curr Opin Infect Dis. 2005 Jun;18(3):211-5. doi: 10.1097/01.qco.0000168380.08895.9a. Curr Opin Infect Dis. 2005. PMID: 15864097 Review.
Cited by
-
Late in the US pandemic, multi-dose BCG vaccines protect against COVID-19 and infectious diseases.iScience. 2024 May 22;27(6):109881. doi: 10.1016/j.isci.2024.109881. eCollection 2024 Jun 21. iScience. 2024. PMID: 39055605 Free PMC article.
-
Non-specific protection against severe COVID-19 associated to typhoid fever and DTP vaccination.Heliyon. 2024 Apr 23;10(9):e29935. doi: 10.1016/j.heliyon.2024.e29935. eCollection 2024 May 15. Heliyon. 2024. PMID: 38707311 Free PMC article.
-
Vaccines and Dementia: Part I. Non-Specific Immune Boosting with BCG: History, Ligands, and Receptors.J Alzheimers Dis. 2024;98(2):343-360. doi: 10.3233/JAD-231315. J Alzheimers Dis. 2024. PMID: 38393912 Free PMC article. Review.
-
Using Geographic Disaggregation to Compare Tuberculosis Epidemiology Among American Indian and Alaska Native Persons-USA, 2010-2020.J Racial Ethn Health Disparities. 2024 Feb 9:10.1007/s40615-024-01919-z. doi: 10.1007/s40615-024-01919-z. Online ahead of print. J Racial Ethn Health Disparities. 2024. PMID: 38334874
-
Effects of Bacillus Calmette-Guérin on immunometabolism, microbiome and liver diseases⋆.Liver Res. 2023 Jun;7(2):116-123. doi: 10.1016/j.livres.2023.05.001. Epub 2023 May 19. Liver Res. 2023. PMID: 38223885 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical