Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis

doi:10.3201/eid1005.030711

Case Reports

. 2004 May;10(5):924-7.

doi: 10.3201/eid1005.030711.

Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis

George A Heckman¹, Cynthia Hawkins, Andrew Morris, Lori L Burrows, Catherine Bergeron

Affiliations

PMID: 15200833
PMCID: PMC3323241
DOI: 10.3201/eid1005.030711

Case Reports

Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis

George A Heckman et al. Emerg Infect Dis. 2004 May.

. 2004 May;10(5):924-7.

doi: 10.3201/eid1005.030711.

Authors

George A Heckman¹, Cynthia Hawkins, Andrew Morris, Lori L Burrows, Catherine Bergeron

Affiliation

¹ Department of Medicine, Hamilton Health Sciences, Freeport Health Centre, Kitchener, Ontario, Canada. heck0@sympatico.ca

PMID: 15200833
PMCID: PMC3323241
DOI: 10.3201/eid1005.030711

Abstract

Dementia developed in a patient with widespread neurologic manifestations; she died within 5 months. Pathologic findings showed granulomatous inflammation with caseation necrosis, foreign body-type giant cells, and proliferative endarteritis with vascular occlusions. Broad-range polymerase chain reaction identified Mycobacterium neoaurum as the possible pathogen. Central nervous system infection by M. neoaurum may result in rapidly progressive dementia.

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Figures

**Figure 1**
Meningeal infiltrate with caseation necrosis surrounded by giant cells. A nearby vessel is surrounded by a mononuclear cell infiltrate (occipital lobe, x250, stained with hematoxylin and eosin–Luxol-fast blue).

**Figure 2**
Proliferative endarteritis. The artery is stenotic and partially occluded by fibrous tissue. The residual lumen is almost completely occupied by recent thrombus (frontal lobe, x160, stained with hematoxylin and eosin–Luxol-fast blue).

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Comment in

Mycobacterium neoaurum contamination.
Han XY. Han XY. Emerg Infect Dis. 2005 Aug;11(8):1316-7; author reply 1317. doi: 10.3201/eid1108.040861. Emerg Infect Dis. 2005. PMID: 16110582 Free PMC article. No abstract available.

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References

1. Heritz DM, Lacroix JM, Batra SD, Jarvi KA, Beheshti B, Mittelman MW. Detection of eubacteria in interstitial cystitis by 16S rDNA amplification. J Urol. 1997;158:2291–5. 10.1016/S0022-5347(01)68237-5 - DOI - PubMed
1. Schmidt TM, Relman DA. Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences. Methods Enzymol. 1994;235:205–22. 10.1016/0076-6879(94)35142-2 - DOI - PubMed
1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997;25:3389–402. 10.1093/nar/25.17.3389 - DOI - PMC - PubMed
1. Tsukumura M, Mizuno S. A new species of rapidly growing scotochromogenic mycobacteria, Mycobacterium neoaurum. Med Biol (Tokyo). 1972;85:229–33.
1. Zanetti S, Faedda R, Fadda G, Dupre I, Molicotti P, Ortu S, et al. Isolation and identification of Mycobacterium neoaurum from a patient with urinary infection. New Microbiol. 2001;24:189–92. - PubMed

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[1] Heritz DM, Lacroix JM, Batra SD, Jarvi KA, Beheshti B, Mittelman MW. Detection of eubacteria in interstitial cystitis by 16S rDNA amplification. J Urol. 1997;158:2291–5. 10.1016/S0022-5347(01)68237-5 - DOI - PubMed

[2] Heritz DM, Lacroix JM, Batra SD, Jarvi KA, Beheshti B, Mittelman MW. Detection of eubacteria in interstitial cystitis by 16S rDNA amplification. J Urol. 1997;158:2291–5. 10.1016/S0022-5347(01)68237-5 - DOI - PubMed

[3] Schmidt TM, Relman DA. Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences. Methods Enzymol. 1994;235:205–22. 10.1016/0076-6879(94)35142-2 - DOI - PubMed

[4] Schmidt TM, Relman DA. Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences. Methods Enzymol. 1994;235:205–22. 10.1016/0076-6879(94)35142-2 - DOI - PubMed

[5] Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997;25:3389–402. 10.1093/nar/25.17.3389 - DOI - PMC - PubMed

[6] Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997;25:3389–402. 10.1093/nar/25.17.3389 - DOI - PMC - PubMed

[7] Tsukumura M, Mizuno S. A new species of rapidly growing scotochromogenic mycobacteria, Mycobacterium neoaurum. Med Biol (Tokyo). 1972;85:229–33.

[8] Tsukumura M, Mizuno S. A new species of rapidly growing scotochromogenic mycobacteria, Mycobacterium neoaurum. Med Biol (Tokyo). 1972;85:229–33.

[9] Zanetti S, Faedda R, Fadda G, Dupre I, Molicotti P, Ortu S, et al. Isolation and identification of Mycobacterium neoaurum from a patient with urinary infection. New Microbiol. 2001;24:189–92. - PubMed

[10] Zanetti S, Faedda R, Fadda G, Dupre I, Molicotti P, Ortu S, et al. Isolation and identification of Mycobacterium neoaurum from a patient with urinary infection. New Microbiol. 2001;24:189–92. - PubMed

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Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis

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