Neurocysticercosis in children: clinical findings and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial in newly diagnosed cases
- PMID: 15259471
- DOI: 10.1016/s0035-9203(03)90075-7
Neurocysticercosis in children: clinical findings and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial in newly diagnosed cases
Abstract
The clinical findings of neurocysticercosis, diagnosed primarily on the basis of computed tomography (CT), and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial were studied in 72 newly diagnosed children aged 1.5-12 years admitted to hospital in New Delhi, India, during March to July 2000. The lesions by initial CT were mostly single with perilesional oedema, and were located in the parietal lobes. The most common clinical finding was partial seizure (79.2%). The outcome of the albendazole trial was assessed through changes in CT lesions and status of seizure after 6 months of follow-up; about 55% of the lesions had disappeared and about 80% of the children were seizure-free. The frequency of healing of CT lesions in the albendazole-treated group and placebo group was 54.2% and 55.2%, respectively, and the frequency of a seizure-free state in the albendazole-treated group and placebo group was 87.5% and 77.5%, respectively; the differences were not statistically significant. Changes in lesions by CT and the recurrence of seizures after 6 months of follow-up were not related to the number of lesions by initial CT and albendazole was not beneficial in neurocysticercosis in children with ring-enhancing lesions in CT.
Similar articles
-
Albendazole therapy in children with focal seizures and single small enhancing computerized tomographic lesions: a randomized, placebo-controlled, double blind trial.Pediatr Infect Dis J. 1998 Aug;17(8):696-700. doi: 10.1097/00006454-199808000-00007. Pediatr Infect Dis J. 1998. PMID: 9726343 Clinical Trial.
-
Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy.J Neurol Neurosurg Psychiatry. 2008 Mar;79(3):272-5. doi: 10.1136/jnnp.2007.128058. Epub 2007 Oct 10. J Neurol Neurosurg Psychiatry. 2008. PMID: 17928325 Clinical Trial.
-
Efficacy of albendazole and short-course dexamethasone treatment in children with 1 or 2 ring-enhancing lesions of neurocysticercosis: a randomized controlled trial.J Pediatr. 2003 Jul;143(1):111-4. doi: 10.1016/S0022-3476(03)00211-7. J Pediatr. 2003. PMID: 12915835 Clinical Trial.
-
Anthelmintics for people with neurocysticercosis.Cochrane Database Syst Rev. 2010 Jan 20;(1):CD000215. doi: 10.1002/14651858.CD000215.pub3. Cochrane Database Syst Rev. 2010. PMID: 20091504 Review.
-
Anthelmintics for people with neurocysticercosis.Cochrane Database Syst Rev. 2010 Mar 17;2010(3):CD000215. doi: 10.1002/14651858.CD000215.pub4. Cochrane Database Syst Rev. 2010. Update in: Cochrane Database Syst Rev. 2021 Jun 1;6:CD000215. doi: 10.1002/14651858.CD000215.pub5. PMID: 20238309 Free PMC article. Updated. Review.
Cited by
-
CystiHuman: A model of human neurocysticercosis.PLoS Comput Biol. 2022 May 19;18(5):e1010118. doi: 10.1371/journal.pcbi.1010118. eCollection 2022 May. PLoS Comput Biol. 2022. PMID: 35587497 Free PMC article.
-
Anthelmintics for people with neurocysticercosis.Cochrane Database Syst Rev. 2021 Jun 1;6(6):CD000215. doi: 10.1002/14651858.CD000215.pub5. Cochrane Database Syst Rev. 2021. PMID: 34060667 Free PMC article.
-
Frequency and Determinant Factors for Calcification in Neurocysticercosis.Clin Infect Dis. 2021 Nov 2;73(9):e2592-e2600. doi: 10.1093/cid/ciaa784. Clin Infect Dis. 2021. PMID: 32556276 Free PMC article.
-
Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination.Parasitology. 2020 Jun;147(7):822-827. doi: 10.1017/S0031182020000505. Epub 2020 Apr 1. Parasitology. 2020. PMID: 32234089 Free PMC article.
-
A Personal Account Regarding the Origin and Evolution of Controversies in the Management of Neurocysticercosis.Am J Trop Med Hyg. 2019 Apr;100(4):780-782. doi: 10.4269/ajtmh.18-0921. Am J Trop Med Hyg. 2019. PMID: 30761985 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources