Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
- PMID: 15289865
Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
Abstract
Aberrant activation of the Wnt signaling pathway plays an important role in the development of solid tumors such as breast and colon cancer. Secreted Frizzled-related protein 1 (SFRP1) is a negative regulator of the Wnt pathway. It has been described that SFRP1 mRNA is strongly down-regulated in breast cancer and a putative tumor suppressor function has been postulated. We have generated and characterized an SFRP1 specific antibody to analyze its expression on protein level and to investigate the association of SFRP1 expression with clinicopathological parameters and patient survival. Analysis of >2000 invasive breast tumors and 56 carcinoma in situ revealed similar frequencies of SFRP1 loss in these tumors (46% and 43% respectively). Therefore, we propose that loss of SFRP1 expression is an early event in breast tumorigenesis. SFRP1 expression was inversely correlated with tumor stage (p<0.001) but not with tumor grade (p=0.14) or lymph node status (p=0.84). Performing a multivariate analysis we could confirm the association between tumor stage and SFRP1 expression (p=0.029). In particular, loss of SFRP1 expression in early stage breast tumors (pT1) was associated with poor prognosis (p=0.04). In conclusion, expression of SFRP1 is commonly lost in breast cancer. SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer.
Similar articles
-
Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment.Cells. 2020 Jan 14;9(1):208. doi: 10.3390/cells9010208. Cells. 2020. PMID: 31947616 Free PMC article. Review.
-
[Epigenetic inactivation of the WNT antagonist SFRP1 in breast cancer].Verh Dtsch Ges Pathol. 2005;89:169-77. Verh Dtsch Ges Pathol. 2005. PMID: 18035687 German.
-
The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation.Oncogene. 2008 Jan 31;27(6):865-76. doi: 10.1038/sj.onc.1210669. Epub 2007 Jul 23. Oncogene. 2008. PMID: 17653090
-
Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma.Oncogene. 2007 Aug 16;26(38):5680-91. doi: 10.1038/sj.onc.1210345. Epub 2007 Mar 12. Oncogene. 2007. PMID: 17353908
-
College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Summary. Members of the Cancer Committee.Arch Pathol Lab Med. 1995 Dec;119(12):1109-12. Arch Pathol Lab Med. 1995. PMID: 7503658 Review. No abstract available.
Cited by
-
SFRP1 decreases WNT-Mediated M2 macrophage marker expression in breast tissue.Cancer Immunol Immunother. 2024 Mar 30;73(5):86. doi: 10.1007/s00262-024-03638-0. Cancer Immunol Immunother. 2024. PMID: 38554160 Free PMC article.
-
MOCAT: multi-omics integration with auxiliary classifiers enhanced autoencoder.BioData Min. 2024 Mar 5;17(1):9. doi: 10.1186/s13040-024-00360-6. BioData Min. 2024. PMID: 38444019 Free PMC article.
-
Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer.Aging (Albany NY). 2023 Nov 13;15(21):12651-12673. doi: 10.18632/aging.205204. Epub 2023 Nov 13. Aging (Albany NY). 2023. PMID: 37963835 Free PMC article.
-
Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer.Oncol Lett. 2023 Sep 21;26(5):477. doi: 10.3892/ol.2023.14065. eCollection 2023 Nov. Oncol Lett. 2023. PMID: 37809047 Free PMC article.
-
Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways.Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303010120. doi: 10.1073/pnas.2303010120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549258 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials