Mitochondrial assembly: protein import
- PMID: 15294046
- DOI: 10.1079/PNS2004342
Mitochondrial assembly: protein import
Abstract
The protein import process of mitochondria is vital for the assembly of the hundreds of nuclear-derived proteins into an expanding organelle reticulum. Most of our knowledge of this complex multisubunit network comes from studies of yeast and fungal systems, with little information known about the protein import process in mammalian cells, particularly skeletal muscle. However, growing evidence indicates that the protein import machinery can respond to changes in the energy status of the cell. In particular, contractile activity, a powerful inducer of mitochondrial biogenesis, has been shown to alter the stoichiometry of the protein import apparatus via changes in several protein import machinery components. These adaptations include the induction of cytosolic molecular chaperones that transport precursors to the matrix, the up-regulation of outer membrane import receptors, and the increase in matrix chaperonins that facilitate the import and proper folding of the protein for subsequent compartmentation in the matrix or inner membrane. The physiological importance of these changes is an increased capacity for import into the organelle at any given precursor concentration. Defects in the protein import machinery components have been associated with mitochondrial disorders. Thus, contractile activity may serve as a possible mechanism for up-regulation of mitochondrial protein import and compensation for mitochondrial phenotype alterations observed in diseased muscle.
Similar articles
-
Mitochondrial preprotein translocases as dynamic molecular machines.FEMS Yeast Res. 2006 Sep;6(6):849-61. doi: 10.1111/j.1567-1364.2006.00134.x. FEMS Yeast Res. 2006. PMID: 16911507 Review.
-
Coordination of metabolic plasticity in skeletal muscle.J Exp Biol. 2006 Jun;209(Pt 12):2265-75. doi: 10.1242/jeb.02182. J Exp Biol. 2006. PMID: 16731803 Review.
-
Mitochondrial biogenesis and the role of the protein import pathway.Med Sci Sports Exerc. 2003 Jan;35(1):86-94. doi: 10.1097/00005768-200301000-00015. Med Sci Sports Exerc. 2003. PMID: 12544641 Review.
-
Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway.Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E29-35. doi: 10.1152/ajpendo.00294.2002. Epub 2002 Sep 17. Am J Physiol Endocrinol Metab. 2003. PMID: 12388124
-
Assembly of the cellular powerhouse: current issues in muscle mitochondrial biogenesis.Exerc Sport Sci Rev. 2000 Apr;28(2):68-73. Exerc Sport Sci Rev. 2000. PMID: 10902088 Review.
Cited by
-
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats.Biogerontology. 2014;15(5):517-534. doi: 10.1007/s10522-014-9526-z. Epub 2014 Aug 10. Biogerontology. 2014. PMID: 25108553 Free PMC article. Review.
-
Skeletal muscle mitochondria and aging: a review.J Aging Res. 2012;2012:194821. doi: 10.1155/2012/194821. Epub 2012 Jul 19. J Aging Res. 2012. PMID: 22888430 Free PMC article.
-
Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches.J Biomed Biotechnol. 2011;2011:810242. doi: 10.1155/2011/810242. Epub 2010 Oct 11. J Biomed Biotechnol. 2011. PMID: 20981256 Free PMC article. Review.
-
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.Neoplasia. 2010 Feb;12(2):150-60. doi: 10.1593/neo.91500. Neoplasia. 2010. PMID: 20126473 Free PMC article.
-
Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator.J Biol Chem. 2009 Sep 18;284(38):26029-39. doi: 10.1074/jbc.M109.026443. Epub 2009 Jul 28. J Biol Chem. 2009. PMID: 19638632 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases