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. 2004 Oct;112(14):1393-7.
doi: 10.1289/ehp.7187.

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study

Carl-Gustaf Bornehag  1 , Jan Sundell, Charles J Weschler, Torben Sigsgaard, Björn Lundgren, Mikael Hasselgren, Linda Hägerhed-Engman
Affiliations

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study

Carl-Gustaf Bornehag et al. Environ Health Perspect. 2004 Oct.

Abstract

Global phthalate ester production has increased from very low levels at the end of World War II to approximately 3.5 million metric tons/year. The aim of the present study was to investigate potential associations between persistent allergic symptoms in children, which have increased markedly in developed countries over the past three decades, and the concentration of phthalates in dust collected from their homes. This investigation is a case-control study nested within a cohort of 10,852 children. From the cohort, we selected 198 cases with persistent allergic symptoms and 202 controls without allergic symptoms. A clinical and a technical team investigated each child and her or his environment. We found higher median concentrations of butyl benzyl phthalate (BBzP) in dust among cases than among controls (0.15 vs. 0.12 mg/g dust). Analyzing the case group by symptoms showed that BBzP was associated with rhinitis (p = 0.001) and eczema (p = 0.001), whereas di(2-ethylhexyl) phthalate (DEHP) was associated with asthma (p = 0.022). Furthermore, dose-response relationships for these associations are supported by trend analyses. This study shows that phthalates, within the range of what is normally found in indoor environments, are associated with allergic symptoms in children. We believe that the different associations of symptoms for the three major phthalates-BBzP, DEHP, and di-n-butyl phthalate-can be explained by a combination of chemical physical properties and toxicologic potential. Given the phthalate exposures of children worldwide, the results from this study of Swedish children have global implications.

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Figures

Figure 1
Figure 1. Geometric mean concentrations (95% CIs) of phthalates (A), BBzP, and (B), DEHP in surface dust from bedrooms of nonatopic and atopic children.
See this image and copyright information in PMC

Comment in

  • Potential selection biases.
    Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T. Bornehag CG, et al. Environ Health Perspect. 2005 Mar;113(3):A152-3. doi: 10.1289/ehp.113-1253785. Environ Health Perspect. 2005. PMID: 15743700 Free PMC article. No abstract available.

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