doi: 10.1042/BST0321081.
Programmed -1 ribosomal frameshifting in the SARS coronavirus
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- PMID: 15506971
- DOI: 10.1042/BST0321081
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Programmed -1 ribosomal frameshifting in the SARS coronavirus
Biochem Soc Trans.
2004 Dec.
Abstract
Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.
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