Autophagy defends cells against invading group A Streptococcus
- PMID: 15528445
- DOI: 10.1126/science.1103966
Autophagy defends cells against invading group A Streptococcus
Abstract
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.
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