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. 2004 Nov 5;306(5698):1037-40.
doi: 10.1126/science.1103966.

Autophagy defends cells against invading group A Streptococcus

Ichiro Nakagawa  1 , Atsuo Amano, Noboru Mizushima, Akitsugu Yamamoto, Hitomi Yamaguchi, Takahiro Kamimoto, Atsuki Nara, Junko Funao, Masanobu Nakata, Kayoko Tsuda, Shigeyuki Hamada, Tamotsu Yoshimori
Affiliations

Autophagy defends cells against invading group A Streptococcus

Ichiro Nakagawa et al. Science. .

Abstract

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

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