Review
doi: 10.1515/BC.2004.120.
Combined transport of water and ions through membrane channels
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- PMID: 15551866
- DOI: 10.1515/BC.2004.120
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Review
Combined transport of water and ions through membrane channels
Biol Chem.
2004 Oct.
Abstract
The coupling of ion and water flow through membrane channels is under dispute. Among all human aquaporins only aquaporin-6 exhibits ion channel activity. Whether aquaporin-6 functions also as a water channel cannot yet be determined with confidence. Similarly, a comparison of single-channel water permeabilities from ion channels and aquaporins suggests that ion channels may play a secondary role as water channels. However, the fraction of absorbed fluid that crosses epithelial ion channels still remains to be determined.
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