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. 2005 Feb;113(7):350-61.
doi: 10.1007/s00412-004-0322-4. Epub 2004 Dec 9.

The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID

Hubert Jäger  1 , Melanie Rauch, Stefan Heidmann
Affiliations

The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID

Hubert Jäger et al. Chromosoma. 2005 Feb.

Abstract

The centromere-specific histone H3 variant CENP-A plays a crucial role in kinetochore specification and assembly. We chose a genetic approach to identify interactors of the Drosophila CENP-A homolog CID. Overexpression of cid in the proliferating eye imaginal disk results in a rough eye phenotype, which is dependent on the ability of the overexpressed protein to localize to the kinetochore. A screen for modifiers of the rough eye phenotype identified mutations in the Drosophila condensin subunit gene Cap-G as interactors. Yeast two-hybrid experiments also reveal an interaction between CID and Cap-G. While chromosome condensation in Cap-G mutant embryos appears largely unaffected, massive defects in sister chromatid segregation occur during mitosis. Taken together, our results suggest a link between the chromatin condensation machinery and kinetochore structure.

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