The signals and pathways activating cellular senescence
- PMID: 15743671
- DOI: 10.1016/j.biocel.2004.10.013
The signals and pathways activating cellular senescence
Abstract
Cellular senescence is a program activated by normal cells in response to various types of stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity and others. Senescence can occur following a period of cellular proliferation or in a rapid manner in response to acute stress. Once cells have entered senescence, they cease to divide and undergo a series of dramatic morphologic and metabolic changes. Cellular senescence is thought to play an important role in tumor suppression and to contribute to organismal aging, but a detailed description of its physiologic occurrence in vivo is lacking. Recent studies have provided important insights regarding the manner by which different stresses and stimuli activate the signaling pathways leading to senescence. These studies reveal that a population of growing cells may suffer from a combination of different physiologic stresses acting simultaneously. The signaling pathways activated by these stresses are funneled to the p53 and Rb proteins, whose combined levels of activity determine whether cells enter senescence. Here we review recent advances in our understanding of the stimuli that trigger senescence, the molecular pathways activated by these stimuli, and the manner by which these signals determine the entry of a population of cells into senescence.
Similar articles
-
Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging.J Cell Physiol. 2007 Mar;210(3):567-74. doi: 10.1002/jcp.20919. J Cell Physiol. 2007. PMID: 17133363 Review.
-
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.Circ Res. 2006 Jul 21;99(2):156-64. doi: 10.1161/01.RES.0000233315.38086.bc. Epub 2006 Jun 22. Circ Res. 2006. PMID: 16794190
-
Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening.Int J Biochem Cell Biol. 2005 Jul;37(7):1407-20. doi: 10.1016/j.biocel.2005.01.010. Int J Biochem Cell Biol. 2005. PMID: 15833273
-
Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides.Exp Cell Res. 2004 Dec 10;301(2):189-200. doi: 10.1016/j.yexcr.2004.08.019. Exp Cell Res. 2004. PMID: 15530855
-
Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review.Biochemistry (Mosc). 1997 Nov;62(11):1306-10. Biochemistry (Mosc). 1997. PMID: 9467855 Review.
Cited by
-
The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults.FASEB J. 2024 Apr 30;38(8):e23621. doi: 10.1096/fj.202302103RRR. FASEB J. 2024. PMID: 38651653
-
Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice.Biology (Basel). 2024 Jan 8;13(1):36. doi: 10.3390/biology13010036. Biology (Basel). 2024. PMID: 38248467 Free PMC article.
-
Group B streptococcus induces cellular senescence in human amnion epithelial cells through a partial interleukin-1-mediated mechanism.Biol Reprod. 2024 Feb 10;110(2):329-338. doi: 10.1093/biolre/ioad149. Biol Reprod. 2024. PMID: 37903065
-
Loss of fragile WWOX gene leads to senescence escape and genome instability.Cell Mol Life Sci. 2023 Oct 28;80(11):338. doi: 10.1007/s00018-023-04950-1. Cell Mol Life Sci. 2023. PMID: 37897534 Free PMC article.
-
Application of Menstrual Blood Derived Stromal (stem) Cells Exert Greater Regenerative Potency Than Fibroblasts/Keratinocytes in Chronic Wounds of Diabetic Mice.Avicenna J Med Biotechnol. 2023 Jul-Sep;15(3):139-156. doi: 10.18502/ajmb.v15i3.12923. Avicenna J Med Biotechnol. 2023. PMID: 37538236 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous