Levetiracetam concentrations in serum and in breast milk at birth and during lactation
- PMID: 15857447
- DOI: 10.1111/j.1528-1167.2005.54804.x
Levetiracetam concentrations in serum and in breast milk at birth and during lactation
Abstract
Purpose: To study the pharmacokinetics of levetiracetam (LEV) at birth, during lactation, and in the nursed infant.
Methods: Eight consecutive breast-feeding women with epilepsy treated with LEV twice daily and their infants were studied.
Results: The mean umbilical cord serum/maternal serum ratio was 1.14 (range, 0.97-1.45) (n = 4). The mean milk/maternal serum concentration ratio was 1.00 (range, 0.76-1.33) at 3 to 5 days after delivery (n = 7). At sampling 2 weeks to 10 months after delivery (n = 5), it was similar (range, 0.85-1.38). At 3 to 5 days after delivery, the infants had very low LEV serum concentrations (<10-15 microM), a finding that persisted during continued breast-feeding. No malformations were detected, and in none of the infants did signs of adverse effects develop.
Conclusions: Our data indicate an extensive transfer of LEV from mother to fetus and into breast milk. However, breast-fed infants had very low LEV serum concentrations, suggesting a rapid elimination of LEV.
Comment in
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Is breast milk the best for babies of mothers on levetiracetam?Epilepsy Curr. 2006 Jan-Feb;6(1):22-4. doi: 10.1111/j.1535-7511.2005.00085.x. Epilepsy Curr. 2006. PMID: 16477320 Free PMC article. No abstract available.
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