Review
doi: 10.1016/j.tibs.2005.03.002.
The mammalian Mediator complex and its role in transcriptional regulation
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- PMID: 15896743
- DOI: 10.1016/j.tibs.2005.03.002
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Review
The mammalian Mediator complex and its role in transcriptional regulation
Trends Biochem Sci.
2005 May.
Abstract
Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.
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