doi: 10.1016/j.bmcl.2005.05.013.
Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
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- PMID: 15927464
- DOI: 10.1016/j.bmcl.2005.05.013
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Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
Bioorg Med Chem Lett.
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Abstract
Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to evaluate antiviral activity. A compound with a three-carbon linker chain connecting two dioxane moieties inhibited virus production by 50% at a concentration of 40 microM, while (R)-hydroxymethyldioxane inhibited virus production by 50% at a concentration of 1 microM. Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1mM.
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