The retinal pigment epithelium in visual function
- PMID: 15987797
- DOI: 10.1152/physrev.00021.2004
The retinal pigment epithelium in visual function
Abstract
Located between vessels of the choriocapillaris and light-sensitive outer segments of the photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in the maintenance of visual function. Increasing knowledge of the multiple functions performed by the RPE improved the understanding of many diseases leading to blindness. This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function. Mutations in genes that are expressed in the RPE can lead to photoreceptor degeneration. On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other.
Similar articles
-
Ion channels in the RPE.Prog Retin Eye Res. 2007 May;26(3):263-301. doi: 10.1016/j.preteyeres.2006.12.002. Epub 2007 Jan 26. Prog Retin Eye Res. 2007. PMID: 17258931 Review.
-
Morphological characterization of the retinal degeneration in three strains of mice carrying the rd-3 mutation.Vis Neurosci. 2005 Nov-Dec;22(6):721-34. doi: 10.1017/S0952523805226044. Vis Neurosci. 2005. PMID: 16469183
-
Progress in retinal sheet transplantation.Prog Retin Eye Res. 2004 Sep;23(5):475-94. doi: 10.1016/j.preteyeres.2004.05.003. Prog Retin Eye Res. 2004. PMID: 15302347 Review.
-
Morphological changes of retinal pigment epithelium and choroid in rd-mice.Exp Eye Res. 1999 Jan;68(1):75-83. doi: 10.1006/exer.1998.0589. Exp Eye Res. 1999. PMID: 9986744
-
A comparison of phagocytosis by the retinal pigment epithelium in normal and delayed amelanotic chickens.Exp Eye Res. 1993 Jun;56(6):625-34. doi: 10.1006/exer.1993.1080. Exp Eye Res. 1993. PMID: 8595805
Cited by
-
Oxidative Stress, Persistent Inflammation and Blood Coagulation Alterations in Serum Proteome of Patients with Neovascular Age-Related Macular Degeneration.Life (Basel). 2024 May 12;14(5):624. doi: 10.3390/life14050624. Life (Basel). 2024. PMID: 38792644 Free PMC article.
-
Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation.World J Diabetes. 2024 May 15;15(5):958-976. doi: 10.4239/wjd.v15.i5.958. World J Diabetes. 2024. PMID: 38766439 Free PMC article.
-
Near Infrared Autofluorescence Lifetime Imaging of Human Retinal Pigment Epithelium Using Adaptive Optics Scanning Light Ophthalmoscopy.Invest Ophthalmol Vis Sci. 2024 May 1;65(5):27. doi: 10.1167/iovs.65.5.27. Invest Ophthalmol Vis Sci. 2024. PMID: 38758638 Free PMC article.
-
Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle.Elife. 2024 May 13;12:RP91141. doi: 10.7554/eLife.91141. Elife. 2024. PMID: 38739438 Free PMC article.
-
Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells.Mol Biol Rep. 2024 May 10;51(1):637. doi: 10.1007/s11033-024-09595-2. Mol Biol Rep. 2024. PMID: 38727927
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources