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. 2005 Oct;6(10):1054-60.
doi: 10.1038/ni1245. Epub 2005 Sep 4.

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

Ryan T Phan  1 , Masumichi Saito, Katia Basso, Huifeng Niu, Riccardo Dalla-Favera
Affiliations

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

Ryan T Phan et al. Nat Immunol. 2005 Oct.

Abstract

The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center formation and has been linked to lymphomagenesis. BCL6 functions by directly binding to specific DNA sequences and suppressing the transcription of target genes. Here we report an alternative mechanism by which BCL6 controls the transcription of genes lacking a BCL6 binding site and show that this mechanism was required for the prevention of tumor suppressor p53-independent cell cycle arrest in germinal center B cells. BCL6 interacted with the transcriptional activator Miz-1 and, via Miz-1, bound to the promoter and suppressed transcription of the cell cycle arrest gene CDKN1A. Through this mechanism, BCL6 may facilitate the proliferative expansion of germinal centers during the normal immune response and, when deregulated, the pathological expansion of B cell lymphomas.

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Comment in

  • A-Miz-ing BCL6.
    Wu X, Jelinek DF. Wu X, et al. Nat Immunol. 2005 Oct;6(10):964-6. doi: 10.1038/ni1005-964. Nat Immunol. 2005. PMID: 16177801 No abstract available.

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