Review
doi: 10.1016/j.coi.2005.09.017.
Epub 2005 Oct 7.
Animal models of arthritis caused by systemic alteration of the immune system
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- PMID: 16214319
- DOI: 10.1016/j.coi.2005.09.017
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Review
Animal models of arthritis caused by systemic alteration of the immune system
Curr Opin Immunol.
2005 Dec.
Abstract
Animal models are instrumental in understanding the etiology and pathogenetic mechanisms of rheumatoid arthritis. Several new mouse models have either been produced, including transgenics, gene-knockouts, and gene knock-ins, or established as a spontaneous disease due to natural gene mutations. These models are suitable for addressing the roles of T cells, autoantibodies, cytokines and innate immunity in the development and progression of rheumatoid arthritis. In particular, they now provide insights into how systemic alterations of the immune system result in a local development of chronic arthritis that leads to joint destruction.
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