In and out: histone variant exchange in chromatin
- PMID: 16257529
- DOI: 10.1016/j.tibs.2005.10.003
In and out: histone variant exchange in chromatin
Abstract
Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes. In contrast to the canonical histones, which are deposited behind the replication fork during S phase, histone variants are incorporated in a process that is independent of DNA replication. Recent studies have shown that distinct multiprotein complexes are responsible for the targeted deposition of histone variants at active genes, centromeres and silent loci. The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.
Similar articles
-
Epigenetic and replacement roles of histone variant H3.3 in reproduction and development.Int J Dev Biol. 2009;53(2-3):231-43. doi: 10.1387/ijdb.082653go. Int J Dev Biol. 2009. PMID: 19412883 Review.
-
Assembly of variant histones into chromatin.Annu Rev Cell Dev Biol. 2005;21:133-53. doi: 10.1146/annurev.cellbio.21.012704.133518. Annu Rev Cell Dev Biol. 2005. PMID: 16212490 Review.
-
Patterning chromatin: form and function for H2A.Z variant nucleosomes.Curr Opin Genet Dev. 2006 Apr;16(2):119-24. doi: 10.1016/j.gde.2006.02.005. Epub 2006 Feb 28. Curr Opin Genet Dev. 2006. PMID: 16503125 Review.
-
Histone H3 variants specify modes of chromatin assembly.Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4(Suppl 4):16477-84. doi: 10.1073/pnas.172403699. Epub 2002 Aug 12. Proc Natl Acad Sci U S A. 2002. PMID: 12177448 Free PMC article. Review.
-
Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.Mol Cell Biol. 2005 Dec;25(23):10639-51. doi: 10.1128/MCB.25.23.10639-10651.2005. Mol Cell Biol. 2005. PMID: 16287874 Free PMC article.
Cited by
-
PICH acts as a force-dependent nucleosome remodeler.Nat Commun. 2022 Nov 25;13(1):7277. doi: 10.1038/s41467-022-35040-8. Nat Commun. 2022. PMID: 36433994 Free PMC article.
-
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles.DNA Repair (Amst). 2022 Aug;116:103355. doi: 10.1016/j.dnarep.2022.103355. Epub 2022 Jun 12. DNA Repair (Amst). 2022. PMID: 35717761 Free PMC article.
-
The Non-Specific Lethal (NSL) Histone Acetyltransferase Complex Transcriptionally Regulates Yin Yang 1-Mediated Cell Proliferation in Human Cells.Int J Mol Sci. 2022 Mar 30;23(7):3801. doi: 10.3390/ijms23073801. Int J Mol Sci. 2022. PMID: 35409160 Free PMC article.
-
Arsenic-induced epigenetic changes in cancer development.Semin Cancer Biol. 2021 Nov;76:195-205. doi: 10.1016/j.semcancer.2021.03.019. Epub 2021 Mar 30. Semin Cancer Biol. 2021. PMID: 33798722 Free PMC article. Review.
-
Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex.Front Genet. 2020 Feb 11;11:35. doi: 10.3389/fgene.2020.00035. eCollection 2020. Front Genet. 2020. PMID: 32117449 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
