Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jan 5;344(1):48-54.
doi: 10.1016/j.virol.2005.09.037.

Poxvirus entry and membrane fusion

Bernard Moss  1
Affiliations
Free article
Review

Poxvirus entry and membrane fusion

Bernard Moss. Virology. .
Free article

Abstract

The study of poxvirus entry and membrane fusion has been invigorated by new biochemical and microscopic findings that lead to the following conclusions: (1) the surface of the mature virion (MV), whether isolated from an infected cell or by disruption of the membrane wrapper of an extracellular virion, is comprised of a single lipid membrane embedded with non-glycosylated viral proteins; (2) the MV membrane fuses with the cell membrane, allowing the core to enter the cytoplasm and initiate gene expression; (3) fusion is mediated by a newly recognized group of viral protein components of the MV membrane, which are conserved in all members of the poxvirus family; (4) the latter MV entry/fusion proteins are required for cell to cell spread necessitating the disruption of the membrane wrapper of extracellular virions prior to fusion; and furthermore (5) the same group of MV entry/fusion proteins are required for virus-induced cell-cell fusion. Future research priorities include delineation of the roles of individual entry/fusion proteins and identification of cell receptors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Biological Characteristics and Pathogenesis of Monkeypox Virus: An Overview.
    Kalaba MH, El-Sherbiny GM, Sharaf MH, Farghal EE. Kalaba MH, et al. Adv Exp Med Biol. 2024;1451:91-109. doi: 10.1007/978-3-031-57165-7_6. Adv Exp Med Biol. 2024. PMID: 38801573 Review.
  • Monkeypox virus genomic accordion strategies.
    Monzón S, Varona S, Negredo A, Vidal-Freire S, Patiño-Galindo JA, Ferressini-Gerpe N, Zaballos A, Orviz E, Ayerdi O, Muñoz-Gómez A, Delgado-Iribarren A, Estrada V, García C, Molero F, Sánchez-Mora P, Torres M, Vázquez A, Galán JC, Torres I, Causse Del Río M, Merino-Diaz L, López M, Galar A, Cardeñoso L, Gutiérrez A, Loras C, Escribano I, Alvarez-Argüelles ME, Del Río L, Simón M, Meléndez MA, Camacho J, Herrero L, Jiménez P, Navarro-Rico ML, Jado I, Giannetti E, Kuhn JH, Sanchez-Lockhart M, Di Paola N, Kugelman JR, Guerra S, García-Sastre A, Cuesta I, Sánchez-Seco MP, Palacios G. Monzón S, et al. Nat Commun. 2024 Apr 18;15(1):3059. doi: 10.1038/s41467-024-46949-7. Nat Commun. 2024. PMID: 38637500 Free PMC article.
  • Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease.
    Mudhasani RR, Golden JW, Adam GC, Hartingh TJ, Kota KP, Ordonez D, Quackenbush CR, Tran JP, Cline C, Williams JA, Zeng X, Olsen DB, Lieberman LA, Boyce C, Ginnetti A, Meinig JM, Panchal RG, Mucker EM. Mudhasani RR, et al. Microbiol Spectr. 2024 Apr 2;12(4):e0358623. doi: 10.1128/spectrum.03586-23. Epub 2024 Feb 23. Microbiol Spectr. 2024. PMID: 38391232 Free PMC article.
  • Monkeypox virus: insights into pathogenesis and laboratory testing methods.
    Kumar A, Singh N, Anvikar AR, Misra G. Kumar A, et al. 3 Biotech. 2024 Mar;14(3):67. doi: 10.1007/s13205-024-03920-z. Epub 2024 Feb 12. 3 Biotech. 2024. PMID: 38357674 Review.
  • Discovering conserved epitopes of Monkeypox: Novel immunoinformatic and machine learning approaches.
    Izadi M, Mirzaei F, Bagherzadeh MA, Ghiabi S, Khalifeh A. Izadi M, et al. Heliyon. 2024 Jan 23;10(3):e24972. doi: 10.1016/j.heliyon.2024.e24972. eCollection 2024 Feb 15. Heliyon. 2024. PMID: 38318007 Free PMC article.
See all "Cited by" articles

Publication types

LinkOut - more resources

-