Comparison of antioxidant enzymes in saliva of elderly smokers and non-smokers
- PMID: 16433640
- DOI: 10.1111/j.1741-2358.2006.00077.x
Comparison of antioxidant enzymes in saliva of elderly smokers and non-smokers
Abstract
Objectives: This study was designed to compare the levels of copper/zinc superoxide dismutase (Cu/Zn SOD), peroxidase (POx) and glutathione peroxidase (GSH-Px) in saliva of smokers and those in saliva of non-smokers.
Methods: Unstimulated saliva samples were collected from 88 elderly males (65 years old or over) who visited a private dental clinic. Forty-four subjects were current smokers (more than 20 cigarettes daily for at least 30 years) and 44 were non-smokers. The levels of salivary thiocyanate, Cu/Zn SOD, GSH-Px, and POx activity were measured using standard procedures.
Results: The mean levels of salivary thiocyanate (SCN(-)) and SOD were significantly higher (p < 0.01) in the smoking group than in the non-smoking group, whereas the specific activity levels of POx and GSH-Px were significantly higher (p < 0.05) in the non-smoking group than in the smoking group. Significant correlation coefficients were found between the levels of SCN(-) and SOD (r = 0.37, p < 0.001). In the non-smoking group, a significant positive association was found between specific activity of POx and age (r = 0.33, p < 0.05).
Conclusion: Measurement of SCN(-) and Cu/Zn SOD in human saliva might be useful for estimating the level of oxidative stress caused by cigarette smoke. Despite increased H2O2 level as a defense system induced by SOD, detoxification of H2O2 might be deteriorated in the oral cavity of elderly smokers.
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