Development of treatment strategies to combat Ebola and Marburg viruses
- PMID: 16441210
- DOI: 10.1586/14787210.4.1.67
Development of treatment strategies to combat Ebola and Marburg viruses
Abstract
Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.
Similar articles
-
Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists.J Virol. 2015 Oct;89(19):9932-8. doi: 10.1128/JVI.01337-15. Epub 2015 Jul 22. J Virol. 2015. PMID: 26202243 Free PMC article.
-
Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.Antiviral Res. 2012 Jan;93(1):23-9. doi: 10.1016/j.antiviral.2011.10.011. Epub 2011 Oct 18. Antiviral Res. 2012. PMID: 22027648
-
Drug targets in infections with Ebola and Marburg viruses.Infect Disord Drug Targets. 2009 Apr;9(2):191-200. doi: 10.2174/187152609787847730. Infect Disord Drug Targets. 2009. PMID: 19275706 Review.
-
Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions.Antiviral Res. 2008 Apr;78(1):150-61. doi: 10.1016/j.antiviral.2008.01.152. Epub 2008 Feb 26. Antiviral Res. 2008. PMID: 18336927 Review.
-
Filoviruses: recent advances and future challenges.Expert Rev Anti Infect Ther. 2006 Dec;4(6):917-21. doi: 10.1586/14787210.4.6.917. Expert Rev Anti Infect Ther. 2006. PMID: 17181407 No abstract available.
Cited by
-
Developments in Negative-Strand RNA Virus Reverse Genetics.Microorganisms. 2024 Mar 11;12(3):559. doi: 10.3390/microorganisms12030559. Microorganisms. 2024. PMID: 38543609 Free PMC article. Review.
-
Development of Small-Molecule Antivirals for Ebola.Med Res Rev. 2015 Nov;35(6):1175-94. doi: 10.1002/med.21355. Epub 2015 Jul 14. Med Res Rev. 2015. PMID: 26172225 Free PMC article. Review.
-
Ebola and Marburg haemorrhagic fever.J Clin Virol. 2015 Mar;64:111-9. doi: 10.1016/j.jcv.2015.01.014. Epub 2015 Jan 23. J Clin Virol. 2015. PMID: 25660265 Free PMC article. Review.
-
Simian hemorrhagic fever virus infection of rhesus macaques as a model of viral hemorrhagic fever: clinical characterization and risk factors for severe disease.Virology. 2011 Dec 20;421(2):129-40. doi: 10.1016/j.virol.2011.09.016. Epub 2011 Oct 19. Virology. 2011. PMID: 22014505 Free PMC article.
-
Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17982-7. doi: 10.1073/pnas.0809698105. Epub 2008 Nov 3. Proc Natl Acad Sci U S A. 2008. PMID: 18981410 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical