Virus entry: open sesame
- PMID: 16497584
- PMCID: PMC7112260
- DOI: 10.1016/j.cell.2006.02.007
Virus entry: open sesame
Abstract
Detailed information about the replication cycle of viruses and their interactions with host organisms is required to develop strategies to stop them. Cell biology studies, live-cell imaging, and systems biology have started to illuminate the multiple and subtly different pathways that animal viruses use to enter host cells. These insights are revolutionizing our understanding of endocytosis and the movement of vesicles within cells. In addition, such insights reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7112260/bin/gr1_lrg.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7112260/bin/gr2_lrg.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7112260/bin/gr3_lrg.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7112260/bin/gr4_lrg.gif)
Similar articles
-
COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms.J Virol. 2019 Dec 12;94(1):e01341-19. doi: 10.1128/JVI.01341-19. Print 2019 Dec 12. J Virol. 2019. PMID: 31597778 Free PMC article.
-
JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin.J Virol. 2019 Apr 3;93(8):e01948-18. doi: 10.1128/JVI.01948-18. Print 2019 Apr 15. J Virol. 2019. PMID: 30700597 Free PMC article.
-
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent Manner.J Virol. 2017 Nov 14;91(23):e01083-17. doi: 10.1128/JVI.01083-17. Print 2017 Dec 1. J Virol. 2017. PMID: 28956766 Free PMC article.
-
Come in and take your coat off - how host cells provide endocytosis for virus entry.Cell Microbiol. 2010 Oct;12(10):1378-88. doi: 10.1111/j.1462-5822.2010.01510.x. Cell Microbiol. 2010. PMID: 20678171 Review.
-
Learning from the viral journey: how to enter cells and how to overcome intracellular barriers to reach the nucleus.AAPS J. 2009 Mar;11(1):65-77. doi: 10.1208/s12248-009-9080-9. Epub 2009 Feb 5. AAPS J. 2009. PMID: 19194803 Free PMC article. Review.
Cited by
-
Rab27a promotes degradation of West Nile virus E protein in the lysosome.iScience. 2024 Mar 19;27(4):109539. doi: 10.1016/j.isci.2024.109539. eCollection 2024 Apr 19. iScience. 2024. PMID: 38715944 Free PMC article.
-
Cell entry of bovine respiratory syncytial virus through clathrin-mediated endocytosis is regulated by PI3K-Akt and Src-JNK pathways.Front Microbiol. 2024 Apr 16;15:1393127. doi: 10.3389/fmicb.2024.1393127. eCollection 2024. Front Microbiol. 2024. PMID: 38690369 Free PMC article.
-
The host mannose-6-phosphate pathway and viral infection.Front Cell Infect Microbiol. 2024 Jan 31;14:1349221. doi: 10.3389/fcimb.2024.1349221. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38357444 Free PMC article. Review.
-
Research Advances on the Role of Lipids in the Life Cycle of Human Coronaviruses.Microorganisms. 2023 Dec 28;12(1):63. doi: 10.3390/microorganisms12010063. Microorganisms. 2023. PMID: 38257890 Free PMC article. Review.
-
Single-Particle Tracking of Virus Entry in Live Cells.Subcell Biochem. 2023;106:153-168. doi: 10.1007/978-3-031-40086-5_5. Subcell Biochem. 2023. PMID: 38159226 Review.
References
-
- Altenburg B.C., Graham D.Y., Estes M.K. Ultrastructural study of rotavirus replication in cultured cells. J. Gen. Virol. 1980;46:75–85. - PubMed
-
- Berger E.A., Murphy P.M., Farber J.M. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 1999;17:657–700. - PubMed
-
- Best S., Le Tissier P., Towers G., Stoye J.P. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature. 1996;382:826–829. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources