Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238
- PMID: 16830891
- DOI: 10.1038/ja.2006.33
Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238
Abstract
A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.
Similar articles
-
HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071.J Antibiot (Tokyo). 2008 Oct;61(10):623-6. doi: 10.1038/ja.2008.82. J Antibiot (Tokyo). 2008. PMID: 19168976
-
A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro.Appl Microbiol Biotechnol. 2009 Jan;81(5):839-45. doi: 10.1007/s00253-008-1684-y. Epub 2008 Sep 20. Appl Microbiol Biotechnol. 2009. PMID: 18810431
-
Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110.J Microbiol Biotechnol. 2007 Aug;17(8):1403-6. J Microbiol Biotechnol. 2007. PMID: 18051613
-
Bioactive products from Streptomyces.Adv Appl Microbiol. 2000;47:113-56. Adv Appl Microbiol. 2000. PMID: 12876796 Review. No abstract available.
-
[The advance on taxonomy of Streptomyces].Wei Sheng Wu Xue Bao. 2001 Feb;41(1):121-6. Wei Sheng Wu Xue Bao. 2001. PMID: 12549202 Review. Chinese. No abstract available.
Cited by
-
Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity.Acta Mater Med. 2022;1(4):445-475. doi: 10.15212/amm-2022-0028. Epub 2022 Nov 15. Acta Mater Med. 2022. PMID: 36588746 Free PMC article.
-
Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium Strain Rhodococcus sp. UR111 Associated with the Soft Coral Nephthea sp.Antibiotics (Basel). 2022 Nov 15;11(11):1631. doi: 10.3390/antibiotics11111631. Antibiotics (Basel). 2022. PMID: 36421275 Free PMC article.
-
Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.Front Pharmacol. 2022 Jul 11;13:929161. doi: 10.3389/fphar.2022.929161. eCollection 2022. Front Pharmacol. 2022. PMID: 35899111 Free PMC article. Review.
-
Promising bioactive compounds from the marine environment and their potential effects on various diseases.J Genet Eng Biotechnol. 2022 Jan 26;20(1):14. doi: 10.1186/s43141-021-00290-4. J Genet Eng Biotechnol. 2022. PMID: 35080679 Free PMC article. Review.
-
Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain.Front Microbiol. 2021 Nov 10;12:773095. doi: 10.3389/fmicb.2021.773095. eCollection 2021. Front Microbiol. 2021. PMID: 34858379 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources