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. 2006;8(4):105.
doi: 10.1186/bcr1521.

Snail in the frame of malignant tumor recurrence

Bram De Craene  1 , Geert Berx
Affiliations

Snail in the frame of malignant tumor recurrence

Bram De Craene et al. Breast Cancer Res. 2006.

Abstract

Snail plays an important role in the epithelial-to-mesenchymal transition during development and in tumor progression. Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells. Recently, a new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model. Comparative transcriptome analysis of human primary breast cancers suggests that elevated Snail expression is correlated with decreased relapse-free survival. Further characterization of Snail as master regulator in this process might enhance our understanding of the molecular and cellular changes during and after breast tumor recurrence.

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Figures

Figure 1
Figure 1
Schematic of local cancer recurrence in a reversible HER2/neu mouse model. Inactivation of HER2/neu expression results in the regression of breast tumors. Both epigenetic selection and a cocktail of extracellular signals can establish a population of Snail expressing cells allowing epithelial-to-mesenchymal transition and survival, eventually leading to mesenchymal recurrences. BMP, bone morphogenetic protein; EGF(-R), epidermal growth factor (-receptor); FGF(-R), fibroblast growth factor (-receptor); MMP, matrix metalloproteinase; PTC, patched; SCF, stem cell factor; Shh, sonic hedgehog; Smo, smoothened; TGF-β(-R), transforming growth factor beta (-receptor); WNT, member of the Wnt family of peptide ligands.
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