Review
doi: 10.1016/j.tibs.2006.07.005.
Epub 2006 Aug 4.
Phagocyte-derived reactive species: salvation or suicide?
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- PMID: 16890439
- DOI: 10.1016/j.tibs.2006.07.005
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Review
Phagocyte-derived reactive species: salvation or suicide?
Trends Biochem Sci.
2006 Sep.
Abstract
Activated phagocytes produce "reactive oxygen, halogen and nitrogen species" that help to kill some types of microorganism. How these species destroy microorganisms remains, however, an enigma: both direct oxidative damage and indirect damage (whereby reactive species promote the actions of other antibacterial agents) are involved, and no single mechanism is likely to account for the killing of all microorganisms. Phagocyte-derived reactive species are known to injure human tissues and to contribute to inflammation. Recently, however, we have learned that they can also be anti-inflammatory by modulating the immune response. These data have implications for the proposed use of antioxidants to treat inflammation.
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