CEACAMs: their role in physiology and pathophysiology
- PMID: 16919437
- PMCID: PMC7127089
- DOI: 10.1016/j.ceb.2006.08.008
CEACAMs: their role in physiology and pathophysiology
Abstract
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo.
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References
-
- Vaughn D.E., Bjorkman P.J. The (Greek) key to structures of neural adhesion molecules. Neuron. 1996;16:261–273. - PubMed
-
- Crossin K.L., Krushel L.A. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev Dyn. 2000;218:260–279. - PubMed
-
- Walsh F.S., Doherty P. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu Rev Cell Dev Biol. 1997;13:425–456. - PubMed
-
- Beauchemin N., Draber P., Dveksler G., Gold P., Gray-Owen S., Grunert F., Hammarstrom S., Holmes K.V., Karlsson A., Kuroki M. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res. 1999;252:243–249. - PubMed
-
- Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9:67–81. - PubMed
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