Vitamin B12, folic acid, and the nervous system
- PMID: 17052662
- DOI: 10.1016/S1474-4422(06)70598-1
Vitamin B12, folic acid, and the nervous system
Abstract
There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people.
Similar articles
-
The neurology of folic acid deficiency.Handb Clin Neurol. 2014;120:927-43. doi: 10.1016/B978-0-7020-4087-0.00061-9. Handb Clin Neurol. 2014. PMID: 24365361 Review.
-
[Does diet affect our mood? The significance of folic acid and homocysteine].Pol Merkur Lekarski. 2009 Feb;26(152):136-41. Pol Merkur Lekarski. 2009. PMID: 19388520 Review. Polish.
-
[Age-associated changes in the metabolism of vitamin B(12) and folic acid: prevalence, aetiopathogenesis and pathophysiological consequences].Z Gerontol Geriatr. 2004 Apr;37(2):109-35. doi: 10.1007/s00391-004-0169-6. Z Gerontol Geriatr. 2004. PMID: 15103481 Review. German.
-
The methionine-homocysteine cycle and its effects on cognitive diseases.Altern Med Rev. 2003 Feb;8(1):7-19. Altern Med Rev. 2003. PMID: 12611557 Review.
-
Folate, vitamin B12, and neuropsychiatric disorders.Nutr Rev. 1996 Dec;54(12):382-90. doi: 10.1111/j.1753-4887.1996.tb03851.x. Nutr Rev. 1996. PMID: 9155210 Review.
Cited by
-
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.Aging (Albany NY). 2024 May 2;16(9):7856-7869. doi: 10.18632/aging.205788. Epub 2024 May 2. Aging (Albany NY). 2024. PMID: 38700503 Free PMC article.
-
Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus.J Clin Med. 2024 Apr 10;13(8):2176. doi: 10.3390/jcm13082176. J Clin Med. 2024. PMID: 38673453 Free PMC article.
-
Serum Biomarker Analysis in Pediatric ADHD: Implications of Homocysteine, Vitamin B12, Vitamin D, Ferritin, and Iron Levels.Children (Basel). 2024 Apr 22;11(4):497. doi: 10.3390/children11040497. Children (Basel). 2024. PMID: 38671715 Free PMC article.
-
Unlocking Cognitive Potential: Association of Sarcopenia and Mediterranean Diet on Cognitive Function in Community-Dwelling Elderly of the Dalmatian Region.Nutrients. 2024 Mar 28;16(7):991. doi: 10.3390/nu16070991. Nutrients. 2024. PMID: 38613024 Free PMC article.
-
Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment.Int J Mol Sci. 2024 Mar 28;25(7):3769. doi: 10.3390/ijms25073769. Int J Mol Sci. 2024. PMID: 38612580 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical