doi: 10.1002/hipo.20238.
Polyribosomes are increased in spines of CA1 dendrites 2 h after the induction of LTP in mature rat hippocampal slices
Affiliations
- PMID: 17094086
- DOI: 10.1002/hipo.20238
Item in Clipboard
Polyribosomes are increased in spines of CA1 dendrites 2 h after the induction of LTP in mature rat hippocampal slices
Hippocampus.
2007.
Abstract
Enduring long-term potentiation (LTP) requires immediate protein synthesis, hence we assessed whether more polyribosomes are present in dendritic spines of mature hippocampal dendrites after the induction of LTP. Reconstructions from serial section transmission electron microscopy (sSTEM) revealed more dendritic polyribosomes 2 h posttetanus, relative to low-frequency stimulation (LFS). Polyribosomes were present in spines of all shapes with larger postsynaptic densities after 2 h, suggesting a coordinated local protein synthesis among many synapses to replenish proteins utilized during an earlier phase of LTP.
Similar articles
-
Chemically induced long-term potentiation increases the number of perforated and complex postsynaptic densities but does not alter dendritic spine volume in CA1 of adult mouse hippocampal slices.Eur J Neurosci. 2005 Jun;21(12):3368-78. doi: 10.1111/j.1460-9568.2005.04174.x. Eur J Neurosci. 2005. PMID: 16026474
-
Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long-term potentiation.Hippocampus. 2018 Jun;28(6):416-430. doi: 10.1002/hipo.22841. Epub 2018 Apr 16. Hippocampus. 2018. PMID: 29575288 Free PMC article.
-
Remodelling of synaptic morphology but unchanged synaptic density during late phase long-term potentiation (LTP): a serial section electron micrograph study in the dentate gyrus in the anaesthetised rat.Neuroscience. 2004;128(2):251-62. doi: 10.1016/j.neuroscience.2004.06.029. Neuroscience. 2004. PMID: 15350638
-
Local protein synthesis, actin dynamics, and LTP consolidation.Curr Opin Neurobiol. 2008 Oct;18(5):524-31. doi: 10.1016/j.conb.2008.09.013. Epub 2008 Oct 14. Curr Opin Neurobiol. 2008. PMID: 18834940 Review.
-
Spine dynamics and synapse remodeling during LTP and memory processes.Prog Brain Res. 2008;169:199-207. doi: 10.1016/S0079-6123(07)00011-8. Prog Brain Res. 2008. PMID: 18394475 Review.
Cited by
-
Conditions for Synaptic Specificity during the Maintenance Phase of Synaptic Plasticity.eNeuro. 2022 May 9;9(3):ENEURO.0064-22.2022. doi: 10.1523/ENEURO.0064-22.2022. Print 2022 May-Jun. eNeuro. 2022. PMID: 35443991 Free PMC article.
-
Structural LTP: from synaptogenesis to regulated synapse enlargement and clustering.Curr Opin Neurobiol. 2020 Aug;63:189-197. doi: 10.1016/j.conb.2020.04.009. Epub 2020 Jul 10. Curr Opin Neurobiol. 2020. PMID: 32659458 Free PMC article. Review.
-
Synaptic Odyssey.J Neurosci. 2020 Jan 2;40(1):61-80. doi: 10.1523/JNEUROSCI.0735-19.2019. J Neurosci. 2020. PMID: 31896563 Free PMC article. No abstract available.
-
Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.Sci Rep. 2019 Mar 7;9(1):3861. doi: 10.1038/s41598-019-40520-x. Sci Rep. 2019. PMID: 30846859 Free PMC article.
-
The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity.Noncoding RNA. 2016 Jan 11;2(1):1. doi: 10.3390/ncrna2010001. Noncoding RNA. 2016. PMID: 29657259 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
