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. 2006 Aug:1073:300-5.
doi: 10.1196/annals.1353.034.

Animal models of pheochromocytoma including NIH initial experience

Shoichiro Ohta  1 , Edwin W Lai, Shun'Ichiro Taniguchi, Arthur S Tischler, Salvatore Alesci, Karel Pacak
Affiliations

Animal models of pheochromocytoma including NIH initial experience

Shoichiro Ohta et al. Ann N Y Acad Sci. 2006 Aug.

Abstract

Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome-related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine-producing metastatic pheochromocytoma in athymic nude mice using tail-vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma.

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