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. 2006 Dec;10(6):454-6.
doi: 10.1016/j.ccr.2006.11.008.

Radiation resistance and stem-like cells in brain tumors

Dolores Hambardzumyan  1 , Massimo Squatrito, Eric C Holland
Affiliations
Free article

Radiation resistance and stem-like cells in brain tumors

Dolores Hambardzumyan et al. Cancer Cell. 2006 Dec.
Free article

Erratum in

  • Cancer Cell. 2007 Jan;11(1):97. Squartro, Massimo [corrected to Squatrito, Massimo]

Abstract

The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients.

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