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Review
. 2007 Jan;8(1):35-46.
doi: 10.1038/nrg2008.

Heterochromatin revisited

Shiv I S Grewal  1 , Songtao Jia
Affiliations
Review

Heterochromatin revisited

Shiv I S Grewal et al. Nat Rev Genet. 2007 Jan.

Abstract

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.

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