[Distorted heterochromatin replication in Drosophila melanogaster polytene chromosomes as a result of euchromatin-heterochromatin rearrangements]
- PMID: 17333934
[Distorted heterochromatin replication in Drosophila melanogaster polytene chromosomes as a result of euchromatin-heterochromatin rearrangements]
Abstract
Studies of the position effect resulting from chromosome rearrangements in Drosophila melanogaster have shown that replication distortions in polytene chromosomes correlate with heritable gene silencing in mitotic cells. Earlier studies mostly focused on the effects of euchromatin--heterochromatin rearrangements on replication and silencing of euchromatic regions adjacent to the heterochromatin breakpoint. This review is based on published original data and considers the effect of rearrangements on heterochromatin: heterochromatin blocks that are normally underrepresented or underreplicated in polytene chromosomes are restored. Euchromatin proved to affect heterochromatin, preventing its underreplication. The effect is opposite to the known inactivation effect, which extends from heterochromatin to euchromatin. The trans-action of heterochromatin blocks on replication of heterochromatin placed within euchromatin is discussed. Distortions of heterochromatin replication in polytene chromosomes are considered to be an important characteristic associated with the functional role of the corresponding genome regions.
Similar articles
-
[Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes].Genetika. 2006 Aug;42(8):1013-28. Genetika. 2006. PMID: 17025152 Review. Russian.
-
Eu-heterochromatic rearrangements induce replication of heterochromatic sequences normally underreplicated in polytene chromosomes of Drosophila melanogaster.Genetics. 2005 Dec;171(4):1673-81. doi: 10.1534/genetics.105.044461. Epub 2005 Jul 14. Genetics. 2005. PMID: 16020783 Free PMC article.
-
Intercalary heterochromatin and genetic silencing.Bioessays. 2003 Nov;25(11):1040-51. doi: 10.1002/bies.10343. Bioessays. 2003. PMID: 14579245 Review.
-
Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes.Chromosoma. 2003 Mar;111(6):377-98. doi: 10.1007/s00412-002-0218-0. Epub 2002 Nov 28. Chromosoma. 2003. PMID: 12644953
-
[Trans-effect of modifiers on position-effect variegation in a set of euchromatin-heterochromatin rearrangements in Drosophila melanogaster].Genetika. 2001 Oct;37(10):1430-4. Genetika. 2001. PMID: 11761621 Russian.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases